Stem cell research in tissue engineering and translational medicine

Ziegler, Mary E.; Widgerow, Alan D.; Evans, Gregory R. D.

doi:10.1016/b978-0-12-824064-9.00014-9

Cited by 1 publication

(1 citation statement)

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“…However, they do not express CD106 which is present in bone marrow stem cells (BMSCs) [ 7 ]. Furthermore, ADSCs possess the same multipotency as BMSCs, but they are isolated in an easier way, in larger numbers, and less invasively [ 8 ]. The use of autologous ADSCs is common in clinical practice because these cells retain their ability for prolonged survival and differentiation while they also have numerous applications in wound healing, lipotransfer for aesthetic or reconstructive reasons, and osteochondral regeneration [ 9 ].…”

Section: Characterization and Isolation Methods Of The Multipotent Adscsmentioning

confidence: 99%

Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration

Papadopoulos,

Piperi,

Korkolopoulou

2024

IJMS

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Adipose-derived stem cells (ADSCs) are mesenchymal stem cells with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets and signaling processes. Recent evidence has shown that ADSC-exos can mediate tissue regeneration through the regulation of the inflammatory response, enhancement of cell proliferation, and induction of angiogenesis. At the same time, they may promote wound healing as well as the remodeling of the extracellular matrix. In combination with scaffolds, they present the future of cell-free therapies and promising adjuncts to reconstructive surgery with diverse tissue-specific functions and minimal adverse effects. In this review, we address the main characteristics and functional properties of ADSC-exos in tissue regeneration and explore their most recent clinical application in wound healing, musculoskeletal regeneration, dermatology, and plastic surgery as well as in tissue engineering.

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Section: Characterization and Isolation Methods Of The Multipotent Adscsmentioning

confidence: 99%