Stem cell responses to plasma surface modified electrospun polyurethane scaffolds

Zandén, Carl; Erkenstam, Nina Hellström; Padel, Thomas; Wittgenstein, Julia von; Liu, Johan; Kuhn, H. Georg

doi:10.1016/j.nano.2014.01.010

Cited by 52 publications

(38 citation statements)

References 47 publications

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“…In particular, neuronal outgrowth and differentiation is sensitive to surface biomolecules, morphologies, and roughness [112]. GO can be functionalized with different functional groups such as amino-, sulfonic acid-, or methoxyl-groups [113].…”

Section: Applications In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Graphene-based materials for tissue engineering

Shin

Jang

et al. 2016

Advanced Drug Delivery Reviews

585

418

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Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and a model system for quantum behavior. The material's excellent electrical conductivity, biocompatibility, surface area and thermal properties are of much interest to the scientific community. Two dimensional graphene materials have been widely used in various biomedical research areas such as bioelectronics, imaging, drug delivery, and tissue engineering. In this review we will highlight the recent applications of graphene-based materials in tissue engineering and regenerative medicine. In particular, we will discuss the application of graphene-based materials in cardiac, neural, bone, cartilage, skeletal muscle, and skin/adipose tissue engineering. We also discuss the potential risk factors of graphene-based materials in tissue engineering. In addition, we will outline the opportunities in the usage of graphene-based materials for clinical applications.

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Section: Applications In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Graphene-based materials for tissue engineering

Shin

Jang

et al. 2016

Advanced Drug Delivery Reviews

585

418

View full text Add to dashboard Cite

show abstract

“…Various peptides 61–63 , often short amino acid sequences of ECM proteins, are also used to increase biocompatibility of scaffold surfaces. Other approaches such as argon plasma 64 , phosphonate groups 65 , or cold atmospheric plasma 66 modifications have also improved adhesion and cellular infiltration and proliferation on scaffolds.…”

Section: Modifications To Controlled Release Polymersmentioning

confidence: 99%

Controlled drug release for tissue engineering

Rambhia

Peter

2015

Journal of Controlled Release

208

115

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Tissue engineering is often referred to as a three-pronged discipline, with each prong corresponding to 1) a 3D material matrix (scaffold), 2) drugs that act on molecular signaling, and 3)regenerative living cells. Herein we focus on reviewing advances in controlled release of drugs from tissue engineering platforms. This review addresses advances in hydrogels and porous scaffolds that are synthesized from natural materials and synthetic polymers for the purposes of controlled release in tissue engineering. We pay special attention to efforts to reduce the burst release effect and to provide sustained and long-term release. Finally, novel approaches to controlled release are described, including devices that allow for pulsatile and sequential delivery. In addition to recent advances, limitations of current approaches and areas of further research are discussed.

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“…Biodegradable polyurethanes (PU) are a viable alternative to biodegradable polyesters, yet it is known that in some cases they trigger a more aggressive immunological response upon implantation [87]. Zandén et al [88,89] published two papers on the influence of O 2 RF low-pressure plasma treatment on the haemocompatibility of PU meshes and their influence on human embryonic stem cells. In both papers, they had to conclude that a plasma treatment as such is insufficient to significantly alter the haemocompatibility or to stimulate the differentiation of stem cells.…”

Section: Electrospinningmentioning

confidence: 99%

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

Mieno¹

2016

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Non-thermal plasma technology is one of those techniques that suffer relatively little from diffusion limits, slow kinetics, and complex geometries compared to more traditional liquid-based chemical surface modification techniques. Combined with a lack of solvents, preservation of the bulk properties, and fast treatment times; it is a well-liked technique for the treatment of materials for biomedical applications. In this book chapter, a review will be given on what the scientific community determined to be essential to obtain appropriate scaffolds for tissue engineering and how plasma scientists have used non-thermal plasma technology to accomplish this. A distinction will be made depending on the scaffold fabrication technique, as each technique has its own set of specific problems that need to be tackled. Fabrication techniques will include traditional fabrication methods, rapid prototyping, and electrospinning. As for the different plasma techniques, both plasma activation and grafting/polymerization will be included in the review and linked to the in-vitro/in-vivo response to these treatments. The literature review itself is preceded by a more general overview on cell communication, giving useful insights on how surface modification strategies should be developed.

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Stem cell responses to plasma surface modified electrospun polyurethane scaffolds

Cited by 52 publications

References 47 publications

Graphene-based materials for tissue engineering

Graphene-based materials for tissue engineering

Controlled drug release for tissue engineering

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

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