Stem cell strategies in burns care

Burd, Andrew; Ahmed, Kawser; Lam, S.S.; Ayyappan, T.; Huang, Lin

doi:10.1016/j.burns.2006.08.031

Cited by 80 publications

(73 citation statements)

References 64 publications

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“…During the past decade, many promising research results indicate that stem cells, thought to be an important potential source of all types of clinically relevant cells, do bring the prospect to replace damaged tissue by the process of regeneration, ever closer to a clinical reality [THOMSON & AL., 1998;ORLIC & AL., 2001;BURD & AL., 2007]. Continuing research on stem cell has increased our understanding of some devastating human diseases like diabetes, cancer, Parkinson's disease and other neurodegenerative diseases [MARTINEZSERRANO & BJORKLUND, 1996;CAO & AL., 2002;DI GIORGIO & AL., 2007].…”

Section: Introductionmentioning

confidence: 94%

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

et al. 2009

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Section: Introductionmentioning

confidence: 94%

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

et al. 2009

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“…Indeed, stem cells have demonstrated potential as an adjunctive therapy to enhance wound healing [5][6][7]. In particular, the Stromal Vascular Fraction (SVF) of adipose tissue represents an innovative therapeutic strategy to promote tissue repair and regeneration [8].…”

Section: Introductionmentioning

confidence: 99%

Uncultured adipose-derived regenerative cells (ADRCs) seeded in collagen scaffold improves dermal regeneration, enhancing early vascularization and structural organization following thermal burns

Foubert

Barillas

Gonzalez

et al. 2015

Burns

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“…doi: 10.7243/2050-1218-3-3 such as growth factors with the aim of recovering body function, and have been applied in clinical studies of skeletal muscle regeneration in trauma patients [7][8][9]. A side from the viability of the cell itself, the extracellular environment is considered one of the most important factors for cell growth into functional tissue.…”

Section: Introductionmentioning

confidence: 99%

Porcine urinary bladder extracellular matrix activates skeletal myogenesis in mouse muscle cryoinjury

Song¹,

Hornsby²,

Stanley³

et al. 2014

J Regen Med Tissue Eng

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Background: Accelerated muscle regeneration is highly desirable after direct injury in trauma patients. Though the advantage of extracellular matrix extracted from porcine urine bladder (UBM) on tissue regeneration is feasible, the mechanisms by which skeletal myogenesis is improved are not clear. The current study aim was to determine whether UBM affects skeletal satellite cells during muscle repair after cryoinjury. Methods: RAG2-/-, γc -/-mice underwent bilateral gluteus muscle cryoinjury under general anesthesia. 200µg UBM suspended in 20 µl of Matrigel solution was implanted on one side of the wound intramuscularly, and 20µl of vehicle was applied on the contralateral side as a sham treatment. Five animals without any operation served as baseline. Mice were sacrificed from days 1 to 28 after injury for muscle tissue collection. Tissue morphology was estimated via H&E staining. Satellite cell proliferation was examined by immunofluorescence staining and western blot. Myogenesis markers were assessed by qPCR. Results: H&E staining results showed that muscle regeneration area increased in both sham and UBM treated muscles following injury. The number of regenerating myotubes was significantly higher in UBM treated tissue at 28 days (p<0.05, vs. sham group). Both Pax7 + and Ki-67 + satellite cell number significantly increased in muscle with UBM treatment compared to sham treated muscles (p<0.05). Protein levels of proliferating cell nuclear antigen (PCNA) were greater in muscle with UBM treatment at day 14 and 28 (p<0.05). MyoD1 and myogenin mRNA levels were also significantly higher in UBM treated animal muscle at day 28 (p<0.05). Conclusion: UBM treatment increased skeletal satellite cell proliferation and myogenic differentiation at 28 days after local muscle injury.

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Stem cell strategies in burns care

Cited by 80 publications

References 64 publications

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

Uncultured adipose-derived regenerative cells (ADRCs) seeded in collagen scaffold improves dermal regeneration, enhancing early vascularization and structural organization following thermal burns

Porcine urinary bladder extracellular matrix activates skeletal myogenesis in mouse muscle cryoinjury

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