Stem cell therapy for Alzheimer’s disease: An overview of experimental models and reality

Qin, Chuan; Wang, Kewei; Zhang, Ling; Bai, Lin

doi:10.1002/ame2.12207

Cited by 26 publications

(17 citation statements)

References 136 publications

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“…BM-derived immature monocytic cells can commit to a microglia-like phenotype, and they harbor several features and functions of native microglia [ 94 ]. Since resident microglia appear to degenerate in AD, Mr BMT compensates for the deficient functions of senescent resident microglia in AD [ 95 ]. ALS is a progressive, fatal neurodegenerative disease.…”

Section: Perspectives and Reflections On Microglial Replacement Therapymentioning

confidence: 99%

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

et al. 2023

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As prominent immune cells in the central nervous system, microglia constantly monitor the environment and provide neuronal protection, which are important functions for maintaining brain homeostasis. In the diseased brain, microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular responses. In this review, we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration. We further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases. Notably, we propose microglial depletion and subsequent repopulation as promising replacement therapy. Although microglial replacement therapy is still in its infancy, it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.

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Section: Perspectives and Reflections On Microglial Replacement Therapymentioning

confidence: 99%

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

et al. 2023

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“…We speculated that novel Acr-based controllable tools for a wide range of applications can be developed using the PICI system with broad-spectrum inhibitors such as AcrIIC1 and AcrIIA5 ( 26 , 27 ). In particular, developing more advanced Acr-based tools to achieve precise, allele-specific and controllable genome editing may provide new opportunities for biomedical applications in the future ( 49 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Rapid characterization of anti-CRISPR proteins and optogenetically engineered variants using a versatile plasmid interference system

Song,

Tian,

et al. 2023

Nucleic Acids Research

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Anti-CRISPR (Acr) proteins are encoded by mobile genetic elements to overcome the CRISPR immunity of prokaryotes, displaying promises as controllable tools for modulating CRISPR-based applications. However, characterizing novel anti-CRISPR proteins and exploiting Acr-related technologies is a rather long and tedious process. Here, we established a versatile plasmid interference with CRISPR interference (PICI) system in Escherichia coli for rapidly characterizing Acrs and developing Acr-based technologies. Utilizing the PICI system, we discovered two novel type II-A Acrs (AcrIIA33 and AcrIIA34), which can inhibit the activity of SpyCas9 by affecting DNA recognition of Cas9. We further constructed a circularly permuted AcrIIA4 (cpA4) protein and developed optogenetically engineered, robust AcrIIA4 (OPERA4) variants by combining cpA4 with the light-oxygen-voltage 2 (LOV2) blue light sensory domain. OPERA4 variants are robust light-dependent tools for controlling the activity of SpyCas9 by approximately 1000-fold change under switching dark-light conditions in prokaryotes. OPERA4 variants can achieve potent light-controllable genome editing in human cells as well. Together, our work provides a versatile screening system for characterizing Acrs and developing the Acr-based controllable tools.

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“…Various types of stem cells have been used in stem cell therapy for AD, and implant procedures for stem cells have been developed [122]. Potential risks of oncogenesis, safety of long-term use, efficiency of reprogramming, and avoidance of immune rejection are considerable safety considerations for stem cell implantation, including that of iPS cells.…”

Section: Conclusion 11mentioning

confidence: 99%

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

Murayama

2023

Exp. Anim.

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Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed.The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention.This review provides past and present therapeutic strategies for the management and treatment of AD.

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Stem cell therapy for Alzheimer’s disease: An overview of experimental models and reality

Cited by 26 publications

References 136 publications

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

Rapid characterization of anti-CRISPR proteins and optogenetically engineered variants using a versatile plasmid interference system

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

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