Stem cell therapy for neurological disorders

Abstract

Stem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of selfregeneration of the central nervous system is highly limited. There is hope that stem cells could replace the damaged neuronal and glial cells, and provide biological and functional restoration based on their properties of self renewal and the ability to give rise to different cells. In recent years, the promising results of research on animal models has led to the establishment of the first clinical trials; although no clear evidence of therapeutic benefit for any of the conditions have been ascertained. Here we give a review of the current strategies of stemcell based therapy for some of the more common neurological disorders, discussing the progress and current challenges, and giving an overview of future perspectives. introductionThere are two basic types of stem cells: 1. Another way to achieve cell replacement is to induce the activity of endogenous neural stem cells located in the central nervous system. These are found in the subventricular zone of the lateral ventricles [8,9] Huntington's disease discussion and conclusionsAs certain neurological diseases currently , 2006, 13, 379-388 [31] Bachoud-Lévi A. C., Gaura V., Brugières P., Lefaucheur J. P., Boissé M.