Stem Cell Therapy for Retinopathy of Prematurity

Fu, Angela Ka Wai Lai Zhong Jie

doi:10.4172/2161-0940.1000126

Cited by 3 publications

(4 citation statements)

References 58 publications

(87 reference statements)

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“…In the eye, identification of ocular SCs first started in the 1970s. The ocular SCs are region-specific and are commonly found in the limbus, conjunctiva and trabecular meshwork [226]. Later, a clinical study investigated SC populations in peripheral blood samples from preterm babies with or without ROP [227].…”

Section: Stem Cell Therapy In Ropmentioning

confidence: 99%

“…It is an effective treatment, yielding more than 40% reduction of unfavorable functional outcomes in the cryotherapy-treated eye of severe ROP infants in 3-month, 10-year and 15-year follow-up CRYO-ROP studies [238,239,240]. However, complications appeared with cryotherapy, such as conjunctival laceration, lid edema, apnea, and vitreous hemorrhage, as well as new retinal detachment [9,226,240]. For the better structural and functional outcomes, laser therapy emerged with less ocular and systemic side effects [9,226,241].…”

Section: Current Treatments In Ropmentioning

confidence: 99%

“…However, complications appeared with cryotherapy, such as conjunctival laceration, lid edema, apnea, and vitreous hemorrhage, as well as new retinal detachment [9,226,240]. For the better structural and functional outcomes, laser therapy emerged with less ocular and systemic side effects [9,226,241]. It has a lower requirement in general anesthesia.…”

Section: Current Treatments In Ropmentioning

confidence: 99%

“…It has a lower requirement in general anesthesia. However, some complications about laser treatment are substantial, such as cataract, intraocular hemorrhage, and cornea and lens burn [226]. Ablative therapy has an effective outcome in ablation of peripheral avascular retina after treatment, but it may occur with systemic complications or unfavorable structural and functional outcomes.…”

Section: Current Treatments In Ropmentioning

confidence: 99%

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Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity

Tsang

Liu

2019

IJMS

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Retinopathy of prematurity (ROP) is a common retinal disease in preterm babies. To prolong the lives of preterm babies, high oxygen is provided to mimic the oxygen level in the intrauterine environment for postnatal organ development. However, hyperoxia-hypoxia induced pathological events occur when babies return to room air, leading to ROP with neuronal degeneration and vascular abnormality that affects retinal functions. With advances in neonatal intensive care, it is no longer uncommon for increased survival of very-low-birth-weight preterm infants, which, therefore, increased the incidence of ROP. ROP is now a major cause of preventable childhood blindness worldwide. Current proven treatment for ROP is limited to invasive retinal ablation, inherently destructive to the retina. The lack of pharmacological treatment for ROP creates a great need for effective and safe therapies in these developing infants. Therefore, it is essential to identify potential therapeutic agents that may have positive ROP outcomes, especially in preserving retinal functions. This review gives an overview of various agents in their efficacy in reducing retinal damages in cell culture tests, animal experiments and clinical studies. New perspectives along the neuroprotective pathways in the developing retina are also reviewed.

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Section: Stem Cell Therapy In Ropmentioning

confidence: 99%