2018
DOI: 10.2147/sccaa.s155410
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Stem cell therapy in autism: recent insights

Abstract: Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properti… Show more

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Cited by 39 publications
(59 citation statements)
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“…Finally, potential exosome therapy, as is the case for all types of cellular therapy [79], will have to be approved by regulatory institutions.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, potential exosome therapy, as is the case for all types of cellular therapy [79], will have to be approved by regulatory institutions.…”
Section: Discussionmentioning
confidence: 99%
“…The potentially high preclinical/clinical relevance of iPSC in the study of cerebral functions and the hope to eventually translate this knowledge into the development of future treatment of clinical conditions [24,25], necessitates the development of protocols that enable to differentiate iPSC into both pyramidal (excitatory) and inhibitory neurons, closely resembling human cortical networks [26][27][28]. One of the final goals of neuroscientists working with iPSC is to use these cells not only for the putative treatment of neurodegenerative disorders such as Parkinson's or Alzheimer's disease but also as a source of cells that may potentially rescue physiological impairments characterizing neurodevelopmental disorders (e.g., ASD, schizophrenia).…”
Section: Ipsc: Origin and Applicationsmentioning
confidence: 99%
“…Currently, there are two broad classes of ASD interventions; comprehensive treatment models which are structured programs, and focused intervention practices that only treat narrow behavioral symptoms (Wong et al, 2015). These focused single medication strategies include pharmaceuticals, nutritional supplements/special diets (e.g., melatonin, gluten-free, caseinfree, vitamins, and minerals), and alternative or complementary medicine (e.g., chelation, neurofeedback, hyperbaric oxygen therapy, acupuncture, and stem cell therapy; Wong et al, 2015;Siniscalco et al, 2018;Medavarapu et al, 2019). Psychotropic drugs may also play a role in the management of some behaviors commonly associated with ASD, such as aggression, severe irritability, and hyperactivity.…”
Section: Introductionmentioning
confidence: 99%