Stem cell transplantation in patients with autonomic neuropathy due to primary (AL) amyloidosis

Abstract

Patients with autonomic neuropathy secondary to AL amyloidosis can undergo autologous stem cell transplantation with relative safety. Autonomic neuropathy is an independent, adverse determinant of survival in these patients.

Immunoglobulin Light-Chain Amyloidosis: From Basics to New Developments in Diagnosis, Prognosis and Therapy

“…Both liver measures can be abnormal in the presence of right heart failure. Basic testing for autonomic dysfunction includes orthostatic blood pressure measurement and evaluation for the loss of beat-to-beat variability on resting electrocardiogram [69]. …”

Epidemiology of AL amyloidosis: a real-world study using US claims data

“…8,9 The extent of cardiac dysfunction is the main determinant of the prognosis of patients with AL amyloidosis, although symptomatic hepatic involvement and autonomic involvement also influence survival. 2,10 The epidemiology of AL amyloidosis in the United States has not been well characterized. A study by Kyle et al with data from 1950 to 1989 on the general population residing in Olmsted County, MN is the most comprehensive epidemiological study to date.…”

A prospective study of nutritional status in immunoglobulin light chain amyloidosis

“…23,24 This prospective observational study provides a platform upon which to base future studies of nutritional intervention in AL amyloidosis. It would be useful to determine whether nutritional status affects tolerability and toxicity of treatment, and hence treatment response.…”