Stem Cells and Cancer Stem Cells: The Jekyll and Hyde Scenario and Their Implications in Stem Cell Therapy

Zaman, Wan Safwani Wan Kamarul; Nurul, Asma Abdullah; Nordin, Fazlina

doi:10.3390/biomedicines9091245

Cited by 12 publications

(13 citation statements)

References 125 publications

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“…Many studies have shown that in some forms of cancer, there are cells with specific stem-like properties called cancer stem cells (CSCs) [ 155 ]. CSCs are considered the “initiating” cells of the tumor and the main reasons behind tumor heterogeneity, resistance to therapy and recurrence [ 156 , 157 ].…”

Section: Parthenolide Selectivity In Tumor Cells and Targeting Cancer...mentioning

confidence: 99%

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

et al. 2022

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Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different types of cell death. Recent findings indicate that these compounds not only inhibit prosurvival transcriptional factors such as NF-kB and STATs but can also determine the activation of specific death pathways, increasing intracellular reactive oxygen species (ROS) production and modifications of Bcl-2 family members. An intriguing property of these compounds is its specific targeting of cancer stem cells. The unusual actions of PN and its analogues make these agents good candidates for molecular targeted cancer therapy.

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Section: Parthenolide Selectivity In Tumor Cells and Targeting Cancer...mentioning

confidence: 99%

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

et al. 2022

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“…However, CSCs can replicate and differentiate in an uncontrolled manner into populations of molecularly and phenotypically altered progenitor cells that may have limitless proliferative and survival potential with more plasticity than progeny of NSCs ( 13 ). Additionally, CSCs and NSCs possess high telomerase activity that prolongs their life span, express similar surface receptors and can stimulate angiogenesis ( 28 ).…”

Section: Cancer Stem Cells (Cscs)mentioning

confidence: 99%

“…NSCs develop through organogenesis to form internal organs, while CSCs have tumorigenic properties and form tumour tissues. Moreover, NSCs have normal karyotyping, whereas CSCs have abnormal karyotyping with genetic alterations ( 28 ). Characteristics of CSCs are summarised in Fig.…”

Section: Cancer Stem Cells (Cscs)mentioning

confidence: 99%

“…Stem cells division and differentiation take place in a specialised microenvironment (the niche) that regulates self-renew of these cells through cell-cell communication or secretion of paracrine factors ( 28 , 29 ). CSCs are population of cancer cells within the cancer microenvironment that consists of various cells, including cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells (ECs) and immune cells (the macrophages, T-cells and natural killer (NK) cells, factors secreted by these cells, such as cytokines and growth factors as well as the extracellular matrix (ECM) ( 28 , 29 ). ECM is a noncellular component of tumour microenvironment composed of glycosaminoglycans, collagens, metalloproteases, hyaluronic acid, polysaccharides, glycoproteins, proteoglycans and other proteins ( 30 ).…”

Section: Cancer Stem Cells (Cscs)mentioning

confidence: 99%

“… Characteristics of CSCs including dysregulated self-renewal and differentiation abilities, apoptosis resistance, expression of specific surface markers, tumorigenic and metastatic ability, stimulation of angiogenesis, plasticity, chemo- and radio-resistance ( 21 , 26 , 28 ). CSCs, cancer stem cells.…”

Section: Figurementioning

confidence: 99%

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Cancer stem cells markers in ovarian cancer: Clinical and therapeutic significance (Review)

Królewska-Daszczyńska

Wendlocha

Smycz‐Kubańska

et al. 2022

Oncol Lett

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Ovarian cancer is a gynecological neoplasm that can be found in women, which, due to diagnostic difficulties, is often detected at advanced stages when treatment becomes a significant problem. Moreover, in a number of cases there is a cancer recurrence and resistance to standard chemotherapy treatment. It has been suggested that cancer stem cells (CSCs) that were not eradicated during therapy may be responsible for this. For this reason, effective therapeutic methods eliminating CSCs are being studied, such as therapy targeting CSCs markers. In addition, numerous studies have also drawn attention to the usefulness of CSCs markers in predicting disease progression and assessing patient's prognosis as well as their importance in the development of treatment resistance. The present review presented research on selected CSCs markers, which may be of significant prognostic and therapeutic importance in ovarian cancer. Contents1. Introduction 2. Cancer stem cells (CSCs) 3. CSCs in ovarian cancer 4. Clinical significance of CSCs markers in ovarian cancer 5. Therapeutic importance of CSCs markers 6. Conclusion PATRYCJA KRÓLEWSKA-DASZCZYŃSKA, DOMINIKA WENDLOCHA, MARTA SMYCZ-KUBAŃSKA, SEBASTIAN STĘPIEŃ and ALEKSANDRA MIELCZAREK-

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Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target

Chen

Zhao

et al. 2022

Journal Cellular Physiology

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Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of cancer has always been an important research direction of scientific research. A number of studies have shown that the apelin/APJ system is involved in the development and poor prognosis of a variety of cancers, such as lung cancer, liver cancer, cholangiocarcinoma, breast cancer, glioblastoma, prostate cancer, ovarian cancer, and so on. Accumulating evidence has also shown that the apelin/APJ system acts as a biomarker and predictor of postoperative effects in multiple cancers, which can also affect the tumor microenvironment and the efficacy of cancer immunotherapy. Considering that the apelin/APJ system may be a potential target for cancer treatment, it is of great significance for the study of new cancer treatment targets. To better understand the role of the apelin/APJ system on the occurrence and development of cancer, this article reviews the role of the apelin/APJ system in the occurrence and development of various cancers, angiogenesis, tumor stem cells, tumor microenvironment, drug resistance, poor prognosis, and the research progress of related anticancer drugs.

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Stem Cells and Cancer Stem Cells: The Jekyll and Hyde Scenario and Their Implications in Stem Cell Therapy

Cited by 12 publications

References 125 publications

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

Cancer stem cells markers in ovarian cancer: Clinical and therapeutic significance (Review)

Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target

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