Stem Cells and Exosomes in Aesthetic Medicine

Semsarzadeh, Nina; Andrasik, Wyatt; Khetarpal, Shilpi

doi:10.1016/j.yacs.2021.01.003

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Although the current limited evidence suggests that the cell-free characteristics of exosomes may minimize the risk of unpredictable patterns that can be associated with stem cell-based therapies, definitive evidence is currently lacking. [60][61][62] PRP is a concentrated, autologous-derived product currently used as an adjunct for regenerative potential, and although reported PRP-based outcomes are via growth factors, the exosome itself stimulates the production of natural growth factors via mRNA activation. 8,9,12,16,27,34,60 Due to laboratory-based production of exosomes, supply is nearly indefinite without human donor-related resource limitation and may contain a higher concentration of active ingredients such as growth factors, mRNAs, and cytokines when compared with PRP.…”

Section: Future Directionsmentioning

confidence: 99%

The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature

Sulaiman

Anderson

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Despite an increasing surge of exosome use throughout the aesthetic arena, a paucity of published exosome-based literature exists. Exosomes are membrane-bound extracellular vesicles derived from various cell types, exerting effects via intercellular communication and regulation of several signaling pathways. The purpose of this review was to summarize published articles elucidating mechanisms and potential applications, report available products and clinical techniques, and prompt further investigation of this emerging treatment within the plastic surgery community. Methods: A literature review was performed using PubMed with keywords exosomes, secretomes, extracellular vesicles, plastic surgery, skin rejuvenation, scar revision, hair growth, body contouring, and breast augmentation. Publications from 2010 to 2021 were analyzed for relevance and level of evidence. A Google search identified exosome distributors, where manufacturing/procurement details, price, efficacy, and clinical indications for use were obtained by direct contact and summarized in table format. Results: Exosomes are currently derived from bone marrow, placental, adipose, and umbilical cord tissue. Laboratory-based exosome studies demonstrate enhanced outcomes in skin rejuvenation, scar revision, hair restoration, and fat graft survival on the macro and micro levels. Clinical studies are limited to anecdotal results. Prices vary considerably from $60 to nearly $5000 based on company, source tissue, and exosome concentration. No exosome-based products are currently Food and Drug Administration–approved. Conclusions: Administered alone or as an adjunct, current reports show promise in several areas of aesthetic plastic surgery. However, ongoing investigation is warranted to further delineate concentration, application, safety profile, and overall outcome efficacy.

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