Stem Cells Combined with Nano Materials–Novel Therapeutics for Central Nervous System Diseases

Ai, Xiaolin; Liang, Ruichao; Wang, Yanchao; Fang, Fang

doi:10.1166/jnn.2016.12743

Cited by 5 publications

(2 citation statements)

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“…Third, heterogeneous cell populations need to be synchronously repaired, and the neural regeneration requires careful and systematic regulation to successfully form a complex neuronal network. [ 55 ] In a word, although large amounts of breakthroughs have been made in the application of NSCs, much work remains to be done before successful clinical translation.…”

Section: Neurological Disordersmentioning

confidence: 99%

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Niu

Zhao

et al. 2023

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Neurological diseases are the foremost cause of disability and the second leading cause of death worldwide. Owing to the special microenvironment of neural tissues and biological characteristics of neural cells, a considerable number of neurological disorders are currently incurable. In the past few years, the development of nanoplatforms based on metal–organic frameworks (MOFs) has broadened opportunities for offering sensitive diagnosis/monitoring and effective therapy of neurology‐related diseases. In this article, the obstacles for neurotherapeutics, including delayed diagnosis and misdiagnosis, the existence of blood brain barrier (BBB), off‐target treatment, irrepressible inflammatory storm/oxidative stress, and irreversible nerve cell death are summarized. Correspondingly, MOFs‐based diagnostic/monitoring strategies such as neuroimaging and biosensors (electrochemistry, fluorometry, colorimetry, electrochemiluminescence, etc.) and MOFs‐based therapeutic strategies including higher BBB permeability, targeting specific lesion sites, attenuation of neuroinflammation/oxidative stress as well as regeneration of nerve cells, are extensively highlighted for the management of neurological diseases. Finally, the challenges of the present research from perspective of clinical translation are discussed, hoping to facilitate interdisciplinary studies at the intersections between MOFs‐based nanoplatforms and neurotheranostics.

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Section: Neurological Disordersmentioning

confidence: 99%

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Niu

Zhao

et al. 2023

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“…For the treatment of CNS diseases, nanoengineered materials are important and helpful for a number of reasons. The materials can first and foremost penetrate the BBB, which is a frequent barrier to CNS-targeted medicines (Srikanth and Kessler, 2012;Ai et al, 2016). In addition, nanomaterials can be created to interact with specific cellular subsets or chemicals, allowing for more targeted treatment.…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

Rhaman

Islam

Akash

et al. 2022

Front. Cell Dev. Biol.

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In recent decades, research scientists, molecular biologists, and pharmacologists have placed a strong emphasis on cutting-edge nanostructured materials technologies to increase medicine delivery to the central nervous system (CNS). The application of nanoscience for the treatment of neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), Huntington’s disease (HD), brain cancer, and hemorrhage has the potential to transform care. Multiple studies have indicated that nanomaterials can be used to successfully treat CNS disorders in the case of neurodegeneration. Nanomedicine development for the cure of degenerative and inflammatory diseases of the nervous system is critical. Nanoparticles may act as a drug transporter that can precisely target sick brain sub-regions, boosting therapy success. It is important to develop strategies that can penetrate the blood–brain barrier (BBB) and improve the effectiveness of medications. One of the probable tactics is the use of different nanoscale materials. These nano-based pharmaceuticals offer low toxicity, tailored delivery, high stability, and drug loading capacity. They may also increase therapeutic effectiveness. A few examples of the many different kinds and forms of nanomaterials that have been widely employed to treat neurological diseases include quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, carbon nanotubes, liposomes, and micelles. These unique qualities, including sensitivity, selectivity, and ability to traverse the BBB when employed in nano-sized particles, make these nanoparticles useful for imaging studies and treatment of NDs. Multifunctional nanoparticles carrying pharmacological medications serve two purposes: they improve medication distribution while also enabling cell dynamics imaging and pharmacokinetic study. However, because of the potential for wide-ranging clinical implications, safety concerns persist, limiting any potential for translation. The evidence for using nanotechnology to create drug delivery systems that could pass across the BBB and deliver therapeutic chemicals to CNS was examined in this study.

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Review on pathogenesis and treatment of Alzheimer's disease

Cai,

Liu,

Fan

2024

Developmental Dynamics

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The rising incidence of Alzheimer's disease (AD) and the associated economic impacts has prompted a global focus in the field. In recent years, there has been a growing understanding of the pathogenic mechanisms of AD, including the aggregation of β‐amyloid, hyperphosphorylated tau, and neuroinflammation. These processes collectively lead to neurodegeneration and cognitive decline, which ultimately results in the loss of autonomy in patients. Currently, there are three main types of AD treatments: clinical tools, pharmacological treatment, and material interventions. This review provides a comprehensive analysis of the underlying etiology and pathogenesis of AD, as well as an overview of the current prevalence of AD treatments. We believe this article can help deepen our understanding of the AD mechanism, and facilitate the clinical translation of scientific research or therapies, to address this global problem of AD.

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Stem Cells Combined with Nano Materials–Novel Therapeutics for Central Nervous System Diseases

Cited by 5 publications

References 0 publications

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

Review on pathogenesis and treatment of Alzheimer's disease

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