Stem Cells for Articular Cartilage Repair and Regeneration

Parate, Dinesh; Zhang, Shipin; Hui, James Hoi Po; Toh, Wei Seong

doi:10.1007/978-3-319-40144-7_7

Cited by 1 publication

(1 citation statement)

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“…In the presence of small amounts of oxygen, an aerobic metabolism occurs. Articular chondrocytes, their metabolism, and generation of different ECM molecules regulate the regeneration and remodeling of articular cartilage [39].…”

Section: Articular Cartilagementioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

107

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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Section: Articular Cartilagementioning

confidence: 99%