Stem Cells for Neonatal Brain Disorders

Ahn, So Yoon; Chang, Yun Sil; Park, Won Soon

doi:10.1159/000444905

Cited by 31 publications

(31 citation statements)

References 49 publications

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“…As the therapeutic efficacy of MSCs seems to be dependent on the paracrine potency of MSCs, the following potential strategies to enhance the paracrine potency of MSCs, including determining the best source, route, timing, and preconditioning approach for MSCs, might improve the therapeutic efficacy of transplanted MSCs (9,35,82,84,94,95).…”

Section: Potential Strategies To Enhance Paracrine Potency Of Stem Cementioning

confidence: 99%

Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders

et al. 2017

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Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment and direct differentiation of transplanted MSCs, and the "hit-and-run" therapeutic effects of these MSCs suggest that their pleiotropic protection might be attributable to paracrine activity via the secretion of various biologic factors rather than to regenerative activity. The transplanted MSCs, therefore, exert their therapeutic effects not by acting as "stem cells," but rather by acting as "paracrine factors factory." The MSCs sense the microenvironment of the injury site and secrete various paracrine factors that serve several reparative functions, including antiapoptotic, anti-inflammatory, antioxidative, antifibrotic, and/or antibacterial effects in response to environmental cues to enhance regeneration of the damaged tissue. Therefore, the therapeutic efficacy of MSCs might be dependent on their paracrine potency. In this review, we focus on recent investigations that elucidate the specifically regulated paracrine mechanisms of MSCs by injury type and discuss potential strategies to enhance paracrine potency, and thus therapeutic efficacy, of transplanted MSCs, including determining the appropriate source and preconditioning strategy for MSCs and the route and timing of their administration.

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Section: Potential Strategies To Enhance Paracrine Potency Of Stem Cementioning

confidence: 99%

Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders

et al. 2017

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“…There have been many recent advances in neonatal intensive care medicine and treatment options [1]; however, Hypoxic Ischemic Encephalopathy (HIE), one of the most prominent neonatal disorders, is still without an effective treatment/cure [1].…”

Section: Introduction Of Hie and Current Treatment Methodsmentioning

confidence: 99%

“…Recovery from HIE depends on certain factors, such as the affected areas in the brain as well as the initial cause of the brain damage in the neonate [4]. A full recovery from HIE is extremely rare and some studies have found that there is a 50% chance of mortality of the neonates that survive with HIE [1], as well as a 25% chance that the neonates that do survive will permanently display cerebral palsy or another type of severe long term brain damage [1]. According to Ahn and his colleagues, there are three stages of HIE: primary/acute phase, latent phase, and a secondary phase [1].…”

Section: Introduction Of Hie and Current Treatment Methodsmentioning

confidence: 99%

“…A full recovery from HIE is extremely rare and some studies have found that there is a 50% chance of mortality of the neonates that survive with HIE [1], as well as a 25% chance that the neonates that do survive will permanently display cerebral palsy or another type of severe long term brain damage [1]. According to Ahn and his colleagues, there are three stages of HIE: primary/acute phase, latent phase, and a secondary phase [1]. The primary/acute phase represents the stage in which some of the neuronal cells undergo apoptosis and the other cells undergo recovery.…”

Section: Introduction Of Hie and Current Treatment Methodsmentioning

confidence: 99%

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Stem Cell Research on Potential Treatment Method for Neonatal Brain Disorder Hypoxic Ischemic Encephalopathy

Donohue¹,

Gallicchio²

2019

Act Scie Pharma

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Despite the groundbreaking scientific breakthroughs occurring today, Hypoxic Ischemic Encephalopathy (HIE) is still one of the most significant causes of fatalities of neonates worldwide. HIE is a type of brain injury that results in neonates losing oxygen and blood flow to the brain. There is currently only one form of treatment for HIE, induced hypothermia. This type of treatment works by delaying the depolarization of anoxic cells so that the affected cell will not go into apoptosis as quickly as it would without treatment. The issue with this treatment is that it is not reliable and only works on neonates with mild to moderate cases of HIE, with little impact on severe cases. Current research suggests mesenchymal stem cells are potential new treatment for HIE due to their ability to be able to differentiate into different types of cells. This review discusses the current research being conducted on stem cells as a potential addition to the already existing treatment method of induced hypothermia, as well as the possible complications and restrictions of using stem cells as a potential treatment method.

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“…The final talk of the SPIN Meeting was by Won Soon Park from Seoul, who discussed stem cell treatment for neonatal brain disorders [15]. This presentation was a logical continuation of Ferreiro's talk, who had set the scene by explaining the vulnerability of the neonatal brain [4].…”

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confidence: 99%