Stem cells for the treatment of neurodegenerative diseases

Abstract

Stem cells offer an enormous pool of resources for the understanding of the human body. One proposed use of stem cells has been as an autologous therapy. The use of stem cells for neurodegenerative diseases has become of interest. Clinical applications of stem cells for Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis will increase in the coming years, and although great care will need to be taken when moving forward with prospective treatments, the application of stem cells is highly promising.

Blastema cells derived from New Zealand white rabbit’s pinna carry stemness properties as shown by differentiation into insulin producing, neural, and osteogenic lineages representing three embryonic germ layers

“…Furthermore, using ESCs in therapeutic procedures may result to tumorigenesis (Dressel et al 2008;BenDavid and Benvenisty 2011). Accordingly, many laboratories have focused on derivation and therapeutic use of other sources of SCs, such as ASCs, which can be used in autologous therapies (Dantuma et al 2010). Nevertheless, ASCs have a lower differentiation capacity, which limits their efficacy for clinical applications (Poulsom et al 2002;Patel and Genovese 2011).…”

Stem Cells: An Answer to Treat Neurodegeneration?

“…Multipotent cells, found in many tissues and organs within the human body, are more limited in their renewal and differentiation and can mainly differentiate into cells of the tissue in which they are found [2]. Naturally occurring stem cells includes embryonic stem cells (ESCs), fetal stem cells (FSCs) and adults stem cells (ASCs).…”

“…The latter cells are termed as induced pluripotent stem (iPS) cells. Specific transcription factors such as Oct4, Sox4, Klf4 and c-Myc are used to induce pluripotency [2]. This discovery revolutionized the field of regenerative medicine.…”

Migration features of labeled bone marrow mesenchymal stem cells in rats with modeled Parkinson-like syndrome

“…Прогресс в развитии клеточной биологии и регенеративной медицины позволяет се-годня надеяться на разработку эффективных методов лечения таких тяжелых нейродегенеративных заболе-ваний, как болезнь Паркинсона, болезнь Альцгеймера, рассеянный склероз, боковой амиотрофический скле-роз, детский церебральный паралич. Заслуживает внимания перспектива применения этого вида терапии при травме спинного и головного мозга, эпилепсии и многих других заболеваниях нервной системы [1][2][3]. Во многих исследованиях установлен положительный эффект при упомянутых заболеваниях введения МСК КМ [4,5].…”