Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy

Nishino, Yudai; Yamada, Yoichi; Ebisawa, Katsumi; Nakamura, Sayaka; Okabe, Kazuto; Umemura, Eri; Hara, Kenji

doi:10.3109/14653249.2010.542462

Cited by 75 publications

(51 citation statements)

References 29 publications

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“…Various studies showed that, as DPSCs, SHEDs have not only interesting in vitro and in vivo TR potential, being able to repair bone, cartilage, blood vessels and adipose tissue, but also a higher proliferation rate, increased population doubling and stemness properties for longer periods, compared to DPSCs and BM-MSCs 28-31 17, 32, 33 . These properties make them a simple, straightforward and convenient source of stem cells for treatment of many current or potential diseases of the pediatric patient, with minimal or no trauma [32][33][34] .…”

Section: Deciduous Teeth and Oral Mucosa: Two Promising Reservoir Of mentioning

confidence: 99%

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Cristaldi¹,

Mauceri²,

Tomasello³

et al. 2018

J Pediatrics & Pediatr Med

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In the last three decades, the constantly increasing need for therapies, efficiently preventing and/or treating human diseases, has raised the interest in Regenerative Medicine (RM). RM is based on employing mesenchymal stem cells (MSCs), that showed to have great proliferation, self-renewal and multilineage differentiation potential, in vitro as well as in vivo. The opportunity of an accessible, painless and low-cost reservoir of MSCs constitutes the first important step of a successful regenerative therapy to include in the current clinical practice. Oral cavity has recently demonstrated to contain different MSCs niches: dental pulp from permanent and deciduous teeth, periodontal ligament, dental follicle, apical papilla and mucosa. MSCs from dental pulp of deciduous teeth, naturally lost in pediatric age, and the oral mucosa have shown to be easily harvested and to have a promising regenerative potential. Thus, the aim of the paper is to review the potentialities of human exfoliated deciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM, with the purpose of their use as accessible source of MSCs for the future of pediatric patient.

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Section: Deciduous Teeth and Oral Mucosa: Two Promising Reservoir Of mentioning

confidence: 99%

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Cristaldi¹,

Mauceri²,

Tomasello³

et al. 2018

J Pediatrics & Pediatr Med

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show abstract

“…They found osteogenically differentiated microspheres with outgrowing cells can be used to fill up bone defects. This new procedure has added advantage of permitting the transplantation of more cells and better integrity compared with cell suspensions or gels (44) . Degenerative bone diseases including TMJ defects can be bioengineered with stem cells.…”

Section: Periodontal Regeneration:-mentioning

confidence: 99%

Stem Cell Regenerative Therapy in Oral and Maxillofacial Region: A Systematic Review.

K¹,

M.²

2017

IJAR

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“…Another suggested application of stem cell therapy for SHEDs is for the treatment of wound healing (Nishino et al, 2011). Using a mouse model, SHEDs were transplanted into an excisional wound and were found to accelerate healing after 5 days when compared to control (Nishino et al, 2011). The potential use of dental stem cells has become even more viable for tissue regeneration and other therapies with the recent advances in cryopreservation.…”

Section: Dental Stem Cells In Tissue Engineering and Regenerative Medmentioning

confidence: 99%

“…The formation of neurons by SHED cells suggests that dental cells may become an invaluable resource for neurodegenerative disease therapies. Another suggested application of stem cell therapy for SHEDs is for the treatment of wound healing (Nishino et al, 2011). Using a mouse model, SHEDs were transplanted into an excisional wound and were found to accelerate healing after 5 days when compared to control (Nishino et al, 2011).…”

Section: Dental Stem Cells In Tissue Engineering and Regenerative Medmentioning

confidence: 99%

Multipotent Dental Stem Cells: An Alternative Adult Derived Stem Cell Source for Regenerative Medicine

Laberge¹,

Cheung²

2011

Embryonic Stem Cells - Differentiation and Pluripotent Alternatives

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Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy

Cited by 75 publications

References 29 publications

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Stem Cell Regenerative Therapy in Oral and Maxillofacial Region: A Systematic Review.

Multipotent Dental Stem Cells: An Alternative Adult Derived Stem Cell Source for Regenerative Medicine

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