Stem Cells in Cartilage Diseases and Repair 2018

Zhang, Jianying; Dong, Shiwu; Sivak, Wesley N.; Sun, Hui; Chang, Peng

doi:10.1155/2018/3672890

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, tissue engineering has raised interest among the scientific community. The rapid development of molecular biology and transplantation techniques has benefitted the application of mesenchymal stem cells and other cell types in regenerative medicine [6,7,8]. Nevertheless, strong efforts continue to be carried out to develop artificial materials that satisfy the very demanding mechanical and tribological requirements and ensure proper performance as AC substitutes [9].…”

Section: Introductionmentioning

confidence: 99%

Tribomechanical Comparison between PVA Hydrogels Obtained Using Different Processing Conditions and Human Cartilage

et al. 2019

View full text Add to dashboard Cite

Designing materials for cartilage replacement raises several challenges due to the complexity of the natural tissue and its unique tribomechanical properties. Poly(vinyl alcohol) (PVA) hydrogels have been explored for such purpose since they are biocompatible, present high chemical stability, and their properties may be tailored through different strategies. In this work, the influence of preparation conditions of PVA hydrogels on its morphology, water absorption capacity, thermotropic behavior, mechanical properties, and tribological performance was evaluated and compared with those of human cartilage (HC). The hydrogels were obtained by cast-drying (CD) and freeze-thawing (FT), in various conditions. It was found that the method of preparation of the PVA hydrogels critically affects their microstructure and performance. CD gels presented a denser structure, absorbed less water, were stiffer, dissipated less energy, and withstood higher loads than FT gels. Moreover, they led to friction coefficients against stainless steel comparable with those of HC. Overall, CD hydrogels had a closer performance to natural HC, when compared to FT ones.

show abstract

Section: Introductionmentioning

confidence: 99%

Tribomechanical Comparison between PVA Hydrogels Obtained Using Different Processing Conditions and Human Cartilage

et al. 2019

View full text Add to dashboard Cite

show abstract

“…125 Tissue-engineering approaches are based on a strategic liaison between cells, scaffolds and signalling molecules to inspire intrinsic repair capacity or rely on extrinsic materials for regeneration. 59,126,127 The spatial complexity of cell types and tissue organization demonstrate that routine biomaterials for bone engineering cannot restore a totally biomimetic structure. It is possible to use novel 3D bioprinting technology to biofabricate skeletal architecture, layer by layer, which is especially significant for cartilage engineering due to its complex nature.…”

Section: Challenges and Strategiesmentioning

confidence: 99%

“…133,134 Stem cells play a fundamental role in cartilage repair. 119,127 In situ biofabrication using adipose-derived mesenchymal stem cells is reportedly feasible for cartilage repair. 124 It is interesting to discern the shift from cartilage- and bone marrow- to adipose-derived cells in clinical translational research, but more phase III trials were based on seed cells from cartilage.…”

Section: Challenges and Strategiesmentioning

confidence: 99%

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques

Gao

et al. 2019

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

It is a great challenge to cure symptomatic lesions and considerable defects of hyaline cartilage due to its complex structure and poor self-repair capacity. If left untreated, unmatured degeneration will cause significant complications. Surgical intervention to repair cartilage may prevent progressive joint degeneration. A series of surgical techniques, including biological augmentation, microfracture and bone marrow stimulation, autologous chondrocyte implantation (ACI), and allogenic and autogenic chondral/osteochondral transplantation, have been used for various indications. However, the limited repairing capacity and the potential pitfalls of these techniques cannot be ignored. Increasing evidence has shown promising outcomes from ACI and cartilage transplantation. Nevertheless, the morbidity of autologous donor sites and limited resource of allogeneic bone have considerably restricted the wide application of these surgical techniques. Costal cartilage, which preserves permanent chondrocytes and the natural osteochondral junction, is an ideal candidate for the restoration of cartilage defects. Several in vitro and in vivo studies have shown good performance of costal cartilage transplantation. Although costal cartilage is a classic donor in plastic and cosmetic surgery, it is rarely used in skeletal cartilage restoration. In this review, we introduce the fundamental properties of costal cartilage and summarize costa-derived chondrocyte implantation and costal chondral/osteochondral transplantation. We will also discuss the pitfalls and pearls of costal cartilage transplantation. Costal chondral/osteochondral transplantation and costa-based chondrocytotherapy might be up-and-coming surgical techniques for recalcitrant cartilage lesions.

show abstract

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

et al. 2020

View full text Add to dashboard Cite

Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skeletal disorders. Mesenchymal stem cells (MSCs) are multipotent stromal cells with mesodermal and neural crest origin. These cells are one of the most attractive candidates in regenerative medicine, and their use could be helpful in repairing and regeneration of skeletal disorders through several mechanisms including homing, angiogenesis, differentiation, and response to inflammatory condition. The most widely studied sources of MSCs are bone marrow (BM), adipose tissue, muscle, umbilical cord (UC), umbilical cord blood (UCB), placenta (PL), Wharton’s jelly (WJ), and amniotic fluid. These cells are capable of differentiating into osteoblasts, chondrocytes, adipocytes, and myocytes in vitro. MSCs obtained from various sources have diverse capabilities of secreting many different cytokines, growth factors, and chemokines. It is believed that the salutary effects of MSCs from different sources are not alike in terms of repairing or reformation of injured skeletal tissues. Accordingly, differential identification of MSCs’ secretome enables us to make optimal choices in skeletal disorders considering various sources. This review discusses and compares the therapeutic abilities of MSCs from different sources for bone and cartilage diseases.

show abstract

Stem Cells in Cartilage Diseases and Repair 2018

Cited by 3 publications

References 6 publications

Tribomechanical Comparison between PVA Hydrogels Obtained Using Different Processing Conditions and Human Cartilage

Tribomechanical Comparison between PVA Hydrogels Obtained Using Different Processing Conditions and Human Cartilage

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

Contact Info

Product

Resources

About