Stem Cells in Pulmonary Disease and Regeneration

Nadkarni, Rohan R.; Abed, Soumeya; Draper, Jonathan S.

doi:10.1016/j.chest.2017.07.021

Cited by 16 publications

(15 citation statements)

References 90 publications

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“…[512][513][514][515][516] This has significant clinical benefits with~85% CR. [512][513][514] Although by definition there are differences between ATRA-based differentiation therapy and adipogenesis-based trans-differentiation therapy, 484,517,518 it is undeniable that APL cells share a great deal in common with EMT-derived carcinoma cells. Specifically, high plasticity and stem cell-like (re-)differentiation capability either empower tumor cells themselves with a spontaneous drugrefractory phenotype or render them vulnerable to a terminal differentiation state through appropriate pharmacological interventions.…”

Section: Transition Between Non-csc and Csc States Definition And Chamentioning

confidence: 99%

Emerging role of tumor cell plasticity in modifying therapeutic response

Qin

Jiang

Lü

et al. 2020

Sig Transduct Target Ther

169

122

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Resistance to cancer therapy is a major barrier to cancer management. Conventional views have proposed that acquisition of resistance may result from genetic mutations. However, accumulating evidence implicates a key role of non-mutational resistance mechanisms underlying drug tolerance, the latter of which is the focus that will be discussed here. Such non-mutational processes are largely driven by tumor cell plasticity, which renders tumor cells insusceptible to the drug-targeted pathway, thereby facilitating the tumor cell survival and growth. The concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial–mesenchymal transition, acquisition properties of cancer stem cells, and trans-differentiation potential during drug exposure. From observations in various cancers, this concept provides an opportunity for investigating the nature of anticancer drug resistance. Over the years, our understanding of the emerging role of phenotype switching in modifying therapeutic response has considerably increased. This expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs, which are likely to improve patient outcomes in clinical practice.

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Section: Transition Between Non-csc and Csc States Definition And Chamentioning

confidence: 99%

Emerging role of tumor cell plasticity in modifying therapeutic response

Qin

Jiang

Lü

et al. 2020

Sig Transduct Target Ther

169

122

View full text Add to dashboard Cite

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“…In the latter, the intrapulmonary airways contain cartilaginous rings, bronchial blood support, submucosal glands, and pseudostratified epithelium. Within the pseudostratified epithelium of terminal and respiratory bronchioles, there are cytokeratins 5 + basal cells which constitute a population of pulmonary stem cells [52]. None of these cells are found in mouse lungs [30,53].…”

Section: Models Of Lung Injurymentioning

confidence: 99%

“…basal, ciliated, goblet, club). Basal cells constitute the primary stem cell population in the lung [52]. In mice, basal cells are present only in the trachea and proximal airways [53].…”

Section: Lung Organoids Confirmed That Diverse Airway Epithelial Stem/progenitor Cells Play Important Role In Airway Repairmentioning

confidence: 99%

Lung organoids, useful tools for investigating epithelial repair after lung injury

et al. 2021

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Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generated. Organoids are applied widely in development, disease modelling, regenerative medicine, and other multiple aspects. Various human pulmonary diseases caused by several factors can be induced and lead to different degrees of lung epithelial injury. Epithelial repair involves the participation of multiple cells and signalling pathways. Lung organoids provide an excellent platform to model injury to and repair of lungs. Here, we review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids. By using lung organoids, we can discover the regulatory mechanisms related to the repair of lung epithelia. This strategy could provide new insights for more effective management of lung diseases and the development of new drugs.

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“…The development of 3D organoid models has created systems capable of emulating human distal lung structures, functions, and cell and matrix interactions, enabling preclinical antifibrotic drug testing [55]. Disrupted distal airway and alveolar epithelia are normally observed in patients suffering from IPF [3]. Endogenous lung epithelial stem/progenitor cell-derived organoid assays provide a unique platform for understanding the mechanisms of adult distal lung diseases.…”

Section: Organoid Modeling Of Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

“…In the lung, damage to the epithelia that cover the conducting airways and alveoli may lead to an inflammatory storm and progressive diseases, including bronchial asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis (IPF), as well as respiratory infections such as the recent coronavirus COVID-19 in China [2]. Region-specific stem/progenitors have been characterized for the maintenance of lung epithelia or to repair the lung epithelia after injury [3]. These epithelial stem/progenitor cells can generate lung organoids that provide a powerful platform for the study of human lung development and respiratory diseases and have therefore attracted intense interest from researchers and physicians.…”

Section: Introductionmentioning

confidence: 99%

Organoids as a Powerful Model for Respiratory Diseases

Liu

Wu²,

Sun³

et al. 2020

Stem Cells International

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Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli. From this perspective, we review the state-of-the-art technology on establishing alveolar organoids from endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as well as the use of alveolar organoids for the study of respiratory diseases, including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory virus infection. We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine.

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Stem Cells in Pulmonary Disease and Regeneration

Cited by 16 publications

References 90 publications

Emerging role of tumor cell plasticity in modifying therapeutic response

Emerging role of tumor cell plasticity in modifying therapeutic response

Lung organoids, useful tools for investigating epithelial repair after lung injury

Organoids as a Powerful Model for Respiratory Diseases

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