Stem cells set their sights on retinitis pigmentosa

Bennicelli, Jeannette L.; Bennett, Jean

doi:10.7554/elife.01291

Cited by 3 publications

(4 citation statements)

References 11 publications

(11 reference statements)

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“…These cells are capable of differentiating into different cell types, indicating that they have the potential to repair tissue and restore function after lesion. Due to this potential, it is believed that stem cells may be able to either replace or repair damaged cells in the retina [199][200][201].…”

Section: Cell-based Therapiesmentioning

confidence: 99%

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

Boia

Ruzafa

Aires

et al. 2020

IJMS

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The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies.

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Section: Cell-based Therapiesmentioning

confidence: 99%

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

Boia

Ruzafa

Aires

et al. 2020

IJMS

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“…ESCs, IPSCs, and MSCs (of bone marrow and adipose tissue origin) are used in stem cell therapy for retinal diseases. 1 , 2 , 3 , 4 , 5 , 8 , 9 …”

Section: Stem Cell Types and Procurementmentioning

confidence: 99%

“…Their unique properties have led to the investigation of stem cells as a treatment option for many diseases. 1 , 2 , 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

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Stem Cell Treatment in Retinal Diseases: Recent Developments

Öner

2018

tjo

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Stem cells are undifferentiated cells which have the ability to self-renew and differentiate into mature cells. They are highly proliferative, implying that an unlimited number of mature cells can be generated from a given stem cell source. On this basis, stem cell replacement therapy has been evaluated in recent years as an alternative for various pathologies. Degenerative retinal diseases cause progressive visual decline which originates from continuing loss of photoreceptor cells and outer nuclear layers. Theoretically, this therapy will enable the generation of new retinal cells from stem cells to replace the damaged cells in the diseased retina. In addition, stem cells are able to perform multiple functions, such as immunoregulation, anti-apoptosis of neurons, and neurotrophin secretion. With recent progress in experimental stem cell applications, phase I/II clinical trials have been approved. These latest stem cell transplantation studies showed that this therapy is a promising approach to restore visual function in eyes with degenerative retinal diseases such as retinitis pigmentosa, Stargardts’ macular dystrophy, and age-related macular degeneration. This review focuses on new developments in stem cell therapy for degenerative retinal diseases.

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