Stem Cells Therapy in General Medicine

Gaipov, Abduzhappar; Myngbay, Askhat

doi:10.29333/ejgm/83014

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Adult stem cells are often utilized in a variety of medical treatments such as bone marrow transplantation. Currently, stem cells can be artificially grown and differentiated into particular cell types with characteristics consistent with cells of different tissues such as nerves or muscles (Gaipov & Myngbay, 2018). Most adult stem cells are multipotent and are commonly referred to by the origin of tissue such as endothelial stem cells, MSCs, and dental pulp stem cells (Barrilleaux, Phinney, Prockop, & O'connor, 2006;Gimble, Katz, & Bunnell, 2007;Salehi et al, 2014;Samiei et al, 2016).…”

Section: Stem Cellsmentioning

confidence: 99%

Stem Cell Therapy: Curcumin Does the Trick

Sharifi

Vahed

Ahmadian

et al. 2019

Phytotherapy Research

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Curcumin is a dietary polyphenol and a bioactive phytochemical agent that possesses anti‐inflammatory, antioxidant, anticancer, and chemopreventive properties. Some of the predominant activities of stem cells include regeneration of identical cells and the ability to maintain the proliferation and multipotentiality. However, these cells could be stimulated to differentiate into specific cell types. Curcumin protects some stem cells from toxicity and can stimulate proliferation and differentiation of stem cells. In the present review, we summarize the antioxidant, stemness activity, antiaging, and neuroprotective as well as wound healing and regenerative effects of curcumin.

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Section: Stem Cellsmentioning

confidence: 99%

Stem Cell Therapy: Curcumin Does the Trick

Sharifi

Vahed

Ahmadian

et al. 2019

Phytotherapy Research

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Reduced inflammation following human endometrial stromal/stem cell injection into male Wistar rats with cisplatin-induced acute kidney injury

et al. 2022

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Introduction: Inflammation is one of the most important mechanisms involved in cisplatin-induced acute kidney injury (AKI). Mesenchymal stromal/stem cells (MSCs) exhibit anti-inflammatory and immunomodulatory abilities. Human endometrial stromal/stem cells (hEnSCs) exhibit similar properties to MSCs. These cells secrete immunoregulators, so we investigated the inflammatory aspect of hEnSCs in the treatment of cisplatin-induced AKI in Wistar rats. Methods: Each group consisted of 6 male Wistar rats. Groups were as follows: sham, model (5 mg/kg cisplatin, IP), and treatment (1 million hEnSCs, IV, 3 hours after cisplatin). Renal function, histopathology, proliferation rate, infiltration of CD3+ T cell, and expression of Il-10 and cystatin c (Cst3) were assessed on day 5. DiI-labeled cells were tracked in kidney and liver on days 4 and 14. Results: HEnSC transplantation improved cisplatin-induced injuries such as renal dysfunction and tissue damage. The highest levels of pathologic scores and hyaline cast formation were observed in the model group while hEnSCs transplantation resulted in their reduction (154.00 ± 14.95, 8.00 ± 1.41 vs. 119.40 ± 5.43, 2.50 ± 1.05). The percentage of Ki-67 positive cells in the treatment group increased while cisplatin decreased proliferation (39.91 ± 5.33 vs. 23.91 ± 3.57 in glomeruli and 39.07 ± 2.95 vs. 16.61 ± 3.25 in tubules). The expression of Cst3 and Il-10 was higher in the model and treatment groups, respectively. DiI-labeled cells were observed in the renal tubules and liver lobes on days 4 and 14. Conclusion: HEnSCs may ameliorate cisplatin-induced AKI through anti-inflammatory and immunomodulatory effects and/or through paracrine effects.

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Stem Cells Therapy in General Medicine

Cited by 2 publications

References 23 publications

Stem Cell Therapy: Curcumin Does the Trick

Stem Cell Therapy: Curcumin Does the Trick

Reduced inflammation following human endometrial stromal/stem cell injection into male Wistar rats with cisplatin-induced acute kidney injury

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