Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

Huang, Jiewu; Kong, Yaozhong; Xie, Chao; Zhou, Lili

doi:10.1186/s13287-021-02266-0

Cited by 37 publications

(24 citation statements)

References 265 publications

(398 reference statements)

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“…Kidney is made up of specialized group of cells, perform specific function, called functional unit of the kidney. 8,9 Therefore, development of NPCs is a better approach for the regeneration of injured or damaged kidney cells. Administrations of progenitor cells have the ability to give rise to any healthy cell type.…”

Section: Resultsmentioning

confidence: 99%

Identification of Nephron Progenitor Cells from WT1 through Amniotic Fluid as a Stem Cell Initiator

Jabeen¹,

Wahid²,

Shaikh³

et al. 2021

PJMHS

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Background: The incidence of kidney disease is prevailing worldwide and there is an urgent requirement for regenerative techniques such as stem cells. Objective: To identify nephron progenitor cells from transcriptional factor WT1. Study Design: Experimental analytical study Place and Duration of Study: Dow Research Institute of Biotechnology & Biomedical Sciences, Dow International Medical College, Karachi from 1st January 2019 to 31stDecember 2019 Methodology: 40 ml of amniotic fluid was extracted from 10 full term women at the time of elective caesarean. Using cell culturing, inverted phase contrast microscopy and flow cytometry techniques in addition to immune-florescence the nephron progenitor cells were identified. Results: The mean age of women was 30.3±0.4 years. Out of total 10 million WT1 expressed in three samples 1.4 million nephron progenitor cells were identified. Conclusion: Identification of nephron progenitor cells is feasible procedure for designing stem cell lines through amniotic fluid. Key words: Progenitor cell, Amniotic fluid, Stem cell initiator

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Section: Resultsmentioning

confidence: 99%

Identification of Nephron Progenitor Cells from WT1 through Amniotic Fluid as a Stem Cell Initiator

Jabeen¹,

Wahid²,

Shaikh³

et al. 2021

PJMHS

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“…Previous studies have reported that an understanding of progenitor cells involved in kidney damage and repair can provide insight into renal pathology and identify novel therapeutic targets [ 56 , 57 ]. Schutgens et al [ 58 ] have demonstrated that TNFRSF19 is a marker gene for epithelial progenitor cells that contributes to adult kidney development in vivo.…”

Section: Discussionmentioning

confidence: 99%

Metabolite Genome-Wide Association Study for Indoleamine 2,3-Dioxygenase Activity Associated with Chronic Kidney Disease

Kim

Jin

Eom

2021

Genes

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Chronic kidney disease (CKD) causes progressive damage to kidney function with increased inflammation. This process contributes to complex amino acid changes. Indoleamine 2,3-dioxygenase (IDO) has been proposed as a new biomarker of CKD in previous studies. In our research, we performed a metabolite genome-wide association study (mGWAS) to identify common and rare variants associated with IDO activity in a Korean population. In addition, single-nucleotide polymorphisms (SNPs) selected through mGWAS were further analyzed for associations with the estimated glomerular filtration rate (eGFR) and CKD. A total of seven rare variants achieved the genome-wide significance threshold (p < 1 × 10−8). Among them, four genes (TNFRSF19, LOC105377444, LOC101928535, and FSTL5) associated with IDO activity showed statistically significant associations with eGFR and CKD. Most of these rare variants appeared specifically in an Asian geographic region. Furthermore, 15 common variants associated with IDO activity were detected in this study and five novel genes (RSU1, PDGFD, SNX25, LOC107984031, and UBASH3B) associated with CKD and eGFR were identified. This study discovered several loci for IDO activity via mGWAS and provided insight into the underlying mechanisms of CKD through association analysis with CKD. To the best of our knowledge, this is the first study to suggest a genetic link between IDO activity and CKD through comparative and integrated analysis.

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“…In recent years, EPCs have been shown to enhance skin wound healing by promoting the formation of new blood vessels in the body's granulation tissue [ 51 ]. Long-term culture of EPCs has been proven to maintain a high proliferation capacity, which can not only stably generate ECs with angiogenic potential in vitro [ 52 ] but also be directly integrated into new blood vessels [ 53 ]. Recent literature has shown that local application of amplified bone marrow-derived EPCs could increase the neovascularization of diabetic skin wounds by releasing cytokines in the local environment of the wound [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Experimental Study on the Effect of Allogeneic Endothelial Progenitor Cells on Wound Healing in Diabetic Mice

Leng

Peng

Pan

et al. 2021

Journal of Diabetes Research

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Endothelial progenitor cells (EPCs) are involved in the neovascularization in traumatic and ischemic sites, but EPCs are “detained” in bone marrow under diabetic conditions, which results in reduction of the number of EPCs and their biological activity in peripheral blood. Based on our previous study to mobilize autologous bone marrow EPCs by administering AMD3100+G-CSF to realize the optimal effect, our present study is aimed at exploring the effects of transplanting EPCs locally in a wound model of diabetic mice. First, we prepared and identified EPCs, and the biological functions and molecular characteristics were compared between EPCs from DB/+ and DB/DB mice. Then, we performed full-thickness skin resection in DB/DB mice and tested the effect of local transplantation of EPCs on skin wound healing. The wound healing process was recorded using digital photographs. The animals were sacrificed on postoperative days 7, 14, and 17 for histological and molecular analysis. Our results showed that DB/+ EPCs were biologically more active than those of DB/DB EPCs. When compared with the control group, local transplantation of EPCs accelerated wound healing in DB/DB mice by promoting wound granulation tissue formation, angiogenesis, and collagen fiber deposition, but there was no significant difference in wound healing between DB/+ EPCs and DB/DB EPCs transplanted into the wound. Furthermore, local transplantation of EPCs promoted the expression of SDF-1, CXCR4, and VEGF. We speculated that EPC transplantation may promote wound healing through the SDF-1/CXCR4 axis. This point is worth exploring further. Present data are of considerable significance because they raise the possibility of promoting wound healing by isolating autologous EPCs from the patient, which provides a new approach for the clinical treatment of diabetic wounds in the future.

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Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

Cited by 37 publications

References 265 publications

Identification of Nephron Progenitor Cells from WT1 through Amniotic Fluid as a Stem Cell Initiator

Identification of Nephron Progenitor Cells from WT1 through Amniotic Fluid as a Stem Cell Initiator

Metabolite Genome-Wide Association Study for Indoleamine 2,3-Dioxygenase Activity Associated with Chronic Kidney Disease

Experimental Study on the Effect of Allogeneic Endothelial Progenitor Cells on Wound Healing in Diabetic Mice

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