Stent conditioned media for in vitro evaluation of hydrophobic stent coatings

Ceresnakova, Miriama; Dully, Michele; Murray, David; Soulimane, Tewfik; Hudson, Sarah P.

doi:10.1016/j.tiv.2021.105212

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…That said, given that Vitamin C is inexpensive and safe, further studies should be conducted to assess its potential against restenosis. Interestingly, Vitamin C promotes EC proliferation while inhibiting VSMC proliferation (Kakade and Mani, 2013;Ceresnakova et al, 2021). This property alone warrants further investigations into the development of stents and balloon releasing Vitamin C, probably in combination with more potent VSMC inhibitors.…”

Section: Targeting Epigenetic Regulatorsmentioning

confidence: 99%

Vascular smooth muscle cells in intimal hyperplasia, an update

2023

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Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia. Intimal hyperplasia develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel’s innermost layer or intima. In this review, we describe the current state of knowledge on the origin and mechanisms underlying the dysregulated proliferation of vascular smooth muscle cells in intimal hyperplasia, and we present the new avenues of research targeting VSMC phenotype and proliferation.

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Section: Targeting Epigenetic Regulatorsmentioning

confidence: 99%

Vascular smooth muscle cells in intimal hyperplasia, an update

2023

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In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

Gniesmer,

Sonntag,

Gapeeva

et al. 2024

Sci Rep

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To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks. The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles. The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber. Animals were euthanized after 2 and 6 weeks for histological evaluation. Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy. Intraocular pressure (IOP) was measured using rebound tonometry. A good tolerability was observed in both short- and medium-term follow-up. Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks. No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks. The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild. The new microshunt reduces the IOP for 2 weeks. Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.

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Stent conditioned media for in vitro evaluation of hydrophobic stent coatings

Cited by 2 publications

References 40 publications

Vascular smooth muscle cells in intimal hyperplasia, an update

Vascular smooth muscle cells in intimal hyperplasia, an update

In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

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