Stent Retriever Thrombectomy in Different Thrombus Locations of Anterior Cerebral Circulation

Abstract

There were no statistically significant differences in the technical or clinical outcomes between the different sites of occlusion (ICA, M1 or M2). There was a non-significant trend towards achieving excellent clinical outcome (3-month mRS ≤ 1) more often and better recanalization results in the two more proximal locations.

Mechanical Thrombectomy for Middle Cerebral Artery Division Occlusions: A Systematic Review and Meta-Analysis

“…The study by Protto et al [38] was excluded as it examined different endpoints based on the same data as from a study [23] by the same author used in our analysis.…”

“…Two of these studies - those by Dorn et al [19,20] - included patients from Germany, one [20] of which was a multicenter study from a stroke registry, and Protto et al [23] looked at patients in Finland. The 3 post hoc analyses [21,22,24] included data from multiple countries.…”

“…After reviewing the abstracts, 25 full-text papers were reviewed for determination of the quality of fit. A total of 6 papers [19,20,21,22,23,24] were left from the full-text review process after excluding abstracts, studies without the relevant outcome of interest, analyses without control groups, or papers with overlapping data (Fig. 1).…”

“…These studies included patients from the MR CLEAN [9] (cutoff time 6 h), STAR [28] (8 h), ESCAPE [10], and DEFUSE 2 [29] (each 12 h) trials. The 3 other studies [19,20,23] did not specify a cutoff time used for MT. There were inconsistencies in reporting of door-to-recanalization times between the studies, with 3 studies reporting mean times [19,20,23], 1 study reporting median times [21], and 2 studies not providing any time to recanalization [22,24].…”

“…The 3 other studies [19,20,23] did not specify a cutoff time used for MT. There were inconsistencies in reporting of door-to-recanalization times between the studies, with 3 studies reporting mean times [19,20,23], 1 study reporting median times [21], and 2 studies not providing any time to recanalization [22,24]. The patients from the MERCI and Multi MERCI studies had significantly longer procedure times, possibly due to different endovascular techniques, less experience, and use of first-generation stent retrievers in these earlier studies.…”