Steps towards Preventive HIV Treatment in Fujian, China: Problems Identified via an Assessment of Initial Antiretroviral Therapy Provision

Xia, Pincang; Okumura, Junko; Yan, Pingping; Xie, Min; Wu, Sen; Zhuang, Meizhu; Zheng, Jin; Zhang, Chunyang; Zhang, Mingya; Kato, Masaya; Cai, Guoxi; Yamamoto, Taro

doi:10.1371/journal.pone.0076483

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Since the first HIV/AIDS case was reported in Fujian Province, southeastern China in 1987, an increasing trend has been seen in the HIV/AIDS epidemic in the province yearly, and a big change is found in the HIV/AIDS epidemic during the last three decades [ 6 ]. Overall, the transmission of HIV/AIDS seems to be classified into three phases based on the epidemic.…”

Section: Introductionmentioning

confidence: 99%

Shift in HIV/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015

Yan-sheng

Liang

et al. 2016

IJERPH

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Objective: The aim of this study was to investigate the shift in the epidemiological features of HIV/AIDS during the last three decades in Fujian Province, southeastern China, so as to provide evidence for the development of novel HIV/AIDS control strategies. Methods: Data pertaining to the conventional surveillance, sentinel surveillance and epidemiological survey in Fujian Province during the period from 1987 to 2015 were collected. The epidemiological trends were described, and the subtypes of HIV strain were genotyped. In addition, the response to antiretroviral therapy was evaluated, and HIV genotypic resistance was assayed. Results: There was an increasing trend observed in the reported cases of HIV/AIDS in Fujian Province. From 1987 to the end of 2015, a total of 8651 HIV/AIDS cases were reported across the province, with totally 1557 deaths found. Among the total cases, the ratio of male/female cases was 3.7:1, which appeared to be an increasing trend; 77.1% cases were detected in young and middle-aged populations aged 19 to 50 years, however, the new HIV infections recently tended to occur in young people aged 15 to 18 years and in populations aged 50 years and older. Among all infected individuals, 49.3% were married, however, the percentage of unmarried cases increased from 6.67% before 1994 to 40.1% in 2015; 64.8% had junior high school education or lower, however, the proportion of HIV/AIDS cases with junior college education or above gradually increased from 6.5% in 2009 to 21.4% in 2015. The reported HIV/AIDS cases were predominantly found in coastal regions; however, a rapidly increasing trend was seen in the number of HIV/AIDS cases in inland regions, and the geographical variation of the cases gradually reduced. There were multiple routes of HIV transmission found in Fujian Province, and 94.2% infections were sexually transmitted, with a large increase in the percentage of male homosexual transmission. A variety of HIV-1 subtypes were genotyped in the province during the study period, and CRF01-AE and CRF07-BC intersubtype recombinant forms were predominant; however, a declining trend in the proportion of HIV-1 CRF01-AE recombinant virus and a significant rise in the proportion of HIV-1 CRF07-BC recombinant virus were observed. Over 90% HIV inhibition was found in all cases receiving antiretroviral therapy during the period from 2011 to 2015, indicating a low prevalence of HIV drug resistance. Conclusions: An increasing trend is still observed in the HIV/AIDS epidemics in Fujian Province, southeastern China. However, the epidemiological pattern of HIV/AIDS has recently changed in the province, and effective control interventions targeting the shift in the epidemiological features of HIV/AIDS should therefore be implemented to control the spread of the epidemic.

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Section: Introductionmentioning

confidence: 99%

Shift in HIV/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015

Yan-sheng

Liang

et al. 2016

IJERPH

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“…This strategy preserved the structural glycan features required for antibody recognition, and allowed the development of natural arrays of uorescent glycans in which the cyclic pyranose structure of the reducing-end sugar residue was retained. 27,28 Although microscale derivatization of individual free glycans offered a rapid route for building a library, the ability to derivatize a glycan mixture from natural sources and to separate them was more attractive. 29 A novel method has been reported for the generation of quantiable glycan libraries by combining the protease digestion of glycoproteins and Fmoc chemistry.…”

Section: Chemo/enzymatic Synthesismentioning

confidence: 99%

Glycan microarrays: new angles and new strategies

Döncző

Kerékgyártó

Szurmai

et al. 2014

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Carbohydrate microarrays, comprising hundreds to thousands of different glycan structures on solid surfaces in a spatially discrete pattern, are sensitive and versatile tools for the analysis of glycosylation changes in complex biological samples. Glycoarrays are also suitable for monitoring multiple molecular interactions with biomolecules where sugars are involved, offering a large variety of bioassay options. In this paper we review the most important glycan microarray types currently used with their main applications, and discuss some of the future challenges the technology faces.

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“…However, people living with HIV (PLWH) can lead long and healthy lives by taking medicines that keep the virus undetectable, and people who maintain an undetectable viral load for at least six months are highly unlikely to transmit HIV through sex ( 1 , 2 ). Since 2013, the Chinese Center for Disease Control and Prevention (CDC) has started a pilot program for early initiation of ART ( 3 ) and then rolled it out across the country in the subsequent years. ART coverage rate among PLWH in China was only 59.0% in 2014, and increased to 83.4% by 2018 ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Perceptions toward antiretroviral therapy and delayed ART initiation among people living with HIV in Changsha, China: mediating effects of treatment willingness

Zhou

Xiao

et al. 2023

Front. Public Health

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IntroductionDelayed antiretroviral therapy (ART) initiation is associated with poor HIV outcomes and a higher likelihood of HIV transmission.MethodsThis cross-sectional study assessed the proportion of delayed ART initiation which was defined as initiating ART after 30 days of HIV diagnosis, and evaluated the pathways influencing ART initiation among adult PLWH in Changsha, China who were diagnosed between 2014 and 2022.ResultsOf 518 participants, 37.8% delayed in initiating ART. Based on the theory of reasoned action (TRA), delayed initiation was indirectly associated with perceptions toward ART through the mediating pathway of patients’ treatment willingness, with treatment willingness significantly being the full mediator.DiscussionThe findings may guide the development of interventions to improve timely uptake of ART in people who are newly diagnosed with HIV.

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Steps towards Preventive HIV Treatment in Fujian, China: Problems Identified via an Assessment of Initial Antiretroviral Therapy Provision

Cited by 4 publications

References 12 publications

Shift in HIV/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015

Shift in HIV/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015

Glycan microarrays: new angles and new strategies

Perceptions toward antiretroviral therapy and delayed ART initiation among people living with HIV in Changsha, China: mediating effects of treatment willingness

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