Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent

Mahdavi, S. Sharareh; Abdekhodaie, Mohammad J.; Kumar, Hitendra; Mashayekhan, Shohreh; Baradaran‐Rafii, Alireza; Kim, Keekyoung

doi:10.1007/s10439-020-02537-6

Cited by 85 publications

(72 citation statements)

References 63 publications

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“…"Vat polymerization printing (VPP)" is distinguished by its setup which comprises a container filled with a cell suspended in photosensitive polymer that is later selectively cured to form 3D structures. [144][145][146][147][148][149][150] In VPP bioprinting, the resin is made up of photosensitive polymers (e.g., polyethylene glycol-diacrylate (PEGDA) and gelatin-methylacryloyl (GelMA)) and photoinitiators (e.g., Eosin Y, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, irgacure). In general, modification of natural biomaterial (e.g., gelatin, collagen, and alginate) is required to modify the polymer's network with the light-sensitive functional group.…”

Section: The Technologymentioning

confidence: 99%

Bioprinting of Collagen: Considerations, Potentials, and Applications

Lee

Suen

Ng³

et al. 2020

Macromolecular Bioscience

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Collagen is the most abundant extracellular matrix protein that is widely used in tissue engineering (TE). There is little research done on printing pure collagen. To understand the bottlenecks in printing pure collagen, it is imperative to understand collagen from a bottom‐up approach. Here it is aimed to provide a comprehensive overview of collagen printing, where collagen assembly in vivo and the various sources of collagen available for TE application are first understood. Next, the current printing technologies and strategy for printing collagen‐based materials are highlighted. Considerations and key challenges faced in collagen printing are identified. Finally, the key research areas that would enhance the functionality of printed collagen are presented.

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Section: The Technologymentioning

confidence: 99%

Bioprinting of Collagen: Considerations, Potentials, and Applications

Lee

Suen

Ng³

et al. 2020

Macromolecular Bioscience

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“…The produced 12.5% GELMA had optical transmittance values of 80‐95% at the edge and 78‐90% at the center. 7.5% GELMA showed lower transmittance value compared to the native corneal tissue 69 …”

Section: Characterization Of Bioprinted Hydrogels For Stroma Tissuementioning

confidence: 75%

“…According to their results, 76% and 70% porosity values were found for 7.5% and 12.5% GELMAs. It was reported that uniform and interconnected pores were obtained from GELMA hydrogels 69 …”

Section: Characterization Of Bioprinted Hydrogels For Stroma Tissuementioning

confidence: 99%

Recent developments and characterization techniques in 3D printing of corneal stroma tissue

Ulag

Uysal

Bedir

et al. 2021

Polymers for Advanced Techs

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Corneal stroma has a significant function in normal visual function. The corneal stroma is vulnerable because of being the thickest part of the cornea, as it can be affected easily by infections or injuries. Any problems on corneal stroma can result in blindness. Donor shortage for corneal transplantation is one of the main issues in corneal transplantation. To address this issue, the corneal tissue engineering focuses on replacing injured tissues and repairing normal functions. Currently, there are no available, engineered corneal tissues for widely accepted routine clinical treatment, but new emerging 3D printing applications are being recognized as a promising option. Recent in vitro researches revealed that the biocompatibility and regeneration possessions of 3D‐printed hydrogels outperformed conventional tissue engineering approaches. The goal of this review is to highlight the current developments in the characterization of 3D cell‐free and bioprinted hydrogels.

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“…Stereolithography bioprinting is based on a gradual, layer-by-layer formation of a programmed structure using radiation, usually in the UV range or laser beam [157,158]. This is achieved through the precise light beam application on the surface of the bioink layer, which is subsequently crosslinked and solidified, after which it is lowered accurately to the height of the created layer and covered with a fresh and uncross-linked bioink, from which another layer can be created until the intended object is produced.…”

Section: D Bioprintingmentioning

confidence: 99%

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy

Płońska‐Brzezińska

2020

Molecules

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Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.

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Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent

Cited by 85 publications

References 63 publications

Bioprinting of Collagen: Considerations, Potentials, and Applications

Bioprinting of Collagen: Considerations, Potentials, and Applications

Recent developments and characterization techniques in 3D printing of corneal stroma tissue

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

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