2023
DOI: 10.20944/preprints202312.1150.v1
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Stereoselective Pharmacokinetics of Ketamine Administered at Low Dose in Awake Dogs

Gwenda Pargätzi,
Alessandra Bergadano,
Claudia Spadavecchia
et al.

Abstract: The present study aimed to examine the stereoselective pharmacokinetics of racemic ketamine in dogs at low dose. Secondary aims were to identify associated behavioural side effects and propose a ketamine infusion rate. The study was conducted on nine intact male beagles, with each dog undergoing two treatments (BOL and INF). For treatment BOL, a single intravenous bolus of 1 mg/kg racemic ketamine was administered over 2 minutes. The treatment INF involved an initial bolus of 0.5 mg/kg given over 1 minute, fol… Show more

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