Stereotactic Body Radiation Therapy for Prostate Cancer: What Is the Appropriate Patient-Reported Outcome for Clinical Trial Design?

Woo, Jennifer A.; Chen, L.N.; Wang, H.; Kim, J.S.; Yung, Thomas M.; Lei, Siyuan; Collins, Brian T.; Suy, Simeng; Dritschilo, Anatoly; Collins, Sean P.

doi:10.1016/j.ijrobp.2014.05.2065

Cited by 1 publication

(3 citation statements)

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“…The results are reported in Table 2 and reveal significant correlation between bowel, urinary, and hormonal function at various timepoints when the coefficient >0.35. EPIC-26 urinary domain appears to have strongest correlation with the ELD-14 burden domain over nearly every time point in follow up (1,3,6,9,18, and 24 mon). In the bowel domain, there is convergence at 6 and 18 months.…”

Section: Resultsmentioning

confidence: 94%

“…The Expanded Prostate Cancer Index Composite (EPIC)-26 is a validated instrument that evaluates urinary, bowel, sexual function and bother, and hormonal outcomes (5). We have employed this questionnaire in our clinic and have previously reported on the use of EPIC-26 to assess for patient reported outcomes (5)(6)(7)(8). Critical gaps remain in our understanding of patients' perceived burden of disease and treatment and its correlation with urinary, bowel, sexual, and hormonal symptoms (6).…”

Section: Introductionmentioning

confidence: 99%

“…We have employed this questionnaire in our clinic and have previously reported on the use of EPIC-26 to assess for patient reported outcomes (5)(6)(7)(8). Critical gaps remain in our understanding of patients' perceived burden of disease and treatment and its correlation with urinary, bowel, sexual, and hormonal symptoms (6). In this report, we seek to correlate the ELD-14 burden domains with the EPIC-26 domains on patient reported outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Self-Reported Burden in Elderly Patients With Localized Prostate Cancer Treated With Stereotactic Body Radiation Therapy (SBRT)

et al. 2020

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Retaining quality of life in patients treated with SBRT for prostate cancer remains paramount. As such, balancing the benefits of treatment against the effects of therapy on elderly patients is essential. The EORTC QLQ-ELD14 (ELD-14) is a validated questionnaire with a domain dedicated to burden of illness and treatment in the elderly. The Expanded Prostate Cancer Index Composite (EPIC)-26 is a validated questionnaire which measures urinary, bowel, sexual, and hormonal symptoms. This study reports trends in self-reported burden in patients with prostate cancer treated with SBRT and reveals convergence of self-reported burden with treatment related side effects obtained from the EPIC-26 questionnaire. Methods: All patients ≥70 years old, with localized prostate cancer treated with SBRT ± ADT at Medstar Georgetown University Hospital from 2013 to 2018 and had completed the ELD-14 were eligible for inclusion in this cross-sectional cohort study. Percentage of responses to questions related to disease and treatment burden were counted for each category ("not at all" and "a little" vs. "quite a bit" and "very much"). Additional demographic features were derived from available medical records. A total of 111 patients (median age of 74) responded to the ELD-14 questionnaire at onset of treatment and at the 2-year mark. Responses to EPIC questionnaires at matched follow-ups were scored and correlated with the self-reported burden domain of the ELD-14 using the Spearman correlation coefficient. Results: Number of patients reporting "quite a bit" or "very much" burden from prostate cancer was 6.3% prior to treatment. This was highest at 1-month (10.8%) and decreased to 9.0% at 24 months post-SBRT (X 2 = 3.836, p = 0.6986). By comparison, 3.6 and 5.4% reported "quite a bit" or "very much" burden from treatment at start of treatment and 24 months, respectively (X 2 =1.046, p = 0.9838). Patient reported treatment burden was found to converge well with individual domains of EPIC-26. Patients undergoing ADT experienced more burden than their non-ADT counterparts. Aghdam et al. Treatment Burden From Prostate SBRT Conclusions: This cross-sectional study suggests a minority of patients reported high burden from their clinically localized prostate cancer or from their SBRT treatment. Self-reported burden converged well with lower EPIC scores in multiple domains.

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Section: Resultsmentioning

confidence: 94%