Stereotactic body radiation therapy for liver metastases: Clinical outcomes and literature review

Peña, Cuauhtémoc de la; González, Mercedes; Gonzalez, Cesar A.; Salazar, Joel M.; Cruz, Benjamín

doi:10.1016/j.rpor.2020.04.021

Cited by 5 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of some prospective studies are summarized in Table 1 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 and some retrospective studies in Table 2 . 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 A recent meta-analysis indicated that the two-year local control (LC) rate was significantly higher in the SBRT group compared to that of the radiofrequency ablation group (83.6% vs. 60.0%, P < 0.001). 41 A systematic review published in 2018 reported that 1- and 2-year overall survival (OS) rates were 67.18% and 56.5%, respectively.…”

Section: Clinical Outcomes Of Sbrtmentioning

confidence: 99%

The evolving role of radiation therapy as treatment for liver metastases

Alrabiah

Liao

Shen

et al. 2022

Journal of the National Cancer Center

View full text Add to dashboard Cite

Section: Clinical Outcomes Of Sbrtmentioning

confidence: 99%

The evolving role of radiation therapy as treatment for liver metastases

Alrabiah

Liao

Shen

et al. 2022

Journal of the National Cancer Center

View full text Add to dashboard Cite

“…Stereotactic Body radiation therapy (SBRT) is a commonly used focal treatment for primary and metastatic liver tumors. 1,2 Liver SBRT delivers a biologically effective dose (BED) of 100 Gy or more over a few (1)(2)(3)(4)(5) treatment fractions. 3 Effective SBRT requires accurate dose delivery to tumors while sparing the sensitive gastrointestinal structures surrounding the tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Stereotactic Body radiation therapy (SBRT) is a commonly used focal treatment for primary and metastatic liver tumors 1,2 . Liver SBRT delivers a biologically effective dose (BED) of 100 Gy or more over a few (1–5) treatment fractions 3 .…”

Section: Introductionmentioning

confidence: 99%

Online verification of breath‐hold reproducibility using kV‐triggered imaging for liver stereotactic body radiation therapy

Guo

Stephans

Woody

et al. 2023

J Applied Clin Med Phys

View full text Add to dashboard Cite

PurposeTo introduce a new technique for online breath‐hold verification for liver stereotactic body radiation therapy (SBRT) based on kilovoltage‐triggered imaging and liver dome positions.Material and MethodsTwenty‐five liver SBRT patients treated with deep inspiration breath‐hold were included in this IRB‐approved study. To verify the breath‐hold reproducibility during treatment, a KV‐triggered image was acquired at the beginning of each breath‐hold. The liver dome position was visually compared with the expected upper/lower liver boundaries created by expanding/contracting the liver contour 5 mm in the superior‐inferior direction. If the liver dome was within the boundaries, delivery continued; otherwise, beam was held manually, and the patient was instructed to take another breath‐hold until the liver dome fell within boundaries. The liver dome was delineated on each triggered image. The mean distance between the delineated liver dome to the projected planning liver contour was defined as liver dome position error edome. The mean and maximum edome of each patient were compared between no breath‐hold verification (all triggered images) and with online breath‐hold verification (triggered images without beam‐hold).ResultsSeven hundred thirteen breath‐hold triggered images from 92 fractions were analyzed. For each patient, an average of 1.5 breath‐holds (range 0–7 for all patients) resulted in beam‐hold, accounting for 5% (0–18%) of all breath‐holds; online breath‐hold verification reduced the mean edome from 3.1 mm (1.3–6.1 mm) to 2.7 mm (1.2–5.2 mm) and the maximum edome from 8.6 mm (3.0–18.0 mm) to 6.7 mm (3.0–9.0 mm). The percentage of breath‐holds with edome >5 mm was reduced from 15% (0–42%) without breath‐hold verification to 11% (0–35%) with online breath‐hold verification. online breath‐hold verification eliminated breath‐holds with edome >10 mm, which happened in 3% (0–17%) of all breath‐holds.ConclusionIt is clinically feasible to monitor the reproducibility of each breath‐hold during liver SBRT treatment using triggered images and liver dome. Online breath‐hold verification improves the treatment accuracy for liver SBRT.

show abstract

“…Stereotactic body radiotherapy (SBRT) consists in a precise delivery of high doses of radiation to an extracranial target in a small number of fractions, sparing surrounding critical tissue. SBRT needs accurate immobilization, a method to manage the respiratory motion of the target and image guidance to ensure proper alignment and delivery of the radiation dose [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Local Treatments in the Unresectable Patient with Colorectal Cancer Metastasis: A Review from the Point of View of the Medical Oncologist

Torres-Jiménez

Esteban-Villarrubia

Ferreiro-Monteagudo

et al. 2021

Cancers

View full text Add to dashboard Cite

For patients with isolated liver metastases from colorectal cancer who are not candidates for potentially curative resections, non-surgical local treatments may be useful. Non-surgical local treatments are classified according to how the treatment is administered. Local treatments are applied directly on hepatic parenchyma, such as radiofrequency, microwave hyperthermia and cryotherapy. Locoregional therapies are delivered through the hepatic artery, such as chemoinfusion, chemoembolization or selective internal radiation with Yttrium 90 radioembolization. The purpose of this review is to describe the different interventional therapies that are available for these patients in routine clinical practice, the most important clinical trials that have tried to demonstrate the effectiveness of each therapy and recommendations from principal medical oncologic societies.

show abstract

Stereotactic body radiation therapy for liver metastases: Clinical outcomes and literature review

Cited by 5 publications

References 40 publications

The evolving role of radiation therapy as treatment for liver metastases

The evolving role of radiation therapy as treatment for liver metastases

Online verification of breath‐hold reproducibility using kV‐triggered imaging for liver stereotactic body radiation therapy

Local Treatments in the Unresectable Patient with Colorectal Cancer Metastasis: A Review from the Point of View of the Medical Oncologist

Contact Info

Product

Resources

About