Stereotactic radiosurgery alone versus resection plus whole‐brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients

Abstract

This article reports an experimental and theoretical study of the peroxide‐induced degradation of polypropylene in a corotating twin‐screw extruder. Experiments were performed with different peroxide concentrations and different operating conditions. The evolution of the chemical reaction along the extruder was monitored with specific sampling devices. Material changes were characterized by rheological measurements and via the determination of the molecular weights of samples collected at the same locations. The theoretical results were obtained with a model that coupled the interactions between flow conditions encountered in the extruder, the kinetics of the reaction, and the changes in the viscosity induced by changes in the molecular weight. The experimental results evidenced the relationships between the process conditions (peroxide concentration and processing parameters) and material properties (rheological properties and molecular structure of the modified polypropylene). Good agreement between the theoretical and experimental results was obtained. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

A Comparison of Radiotherapy with Radiotherapy plus Surgery for Brain Metastases from Urinary Bladder Cancer

“…Therefore, SRS represents a valuable alternative choice in certain patients [25,35] characterized by a high LC response rate and low morbidity, as in our present work. Previous analyses have demonstrated a clear LC and, in some cases, OS benefit for SRS in patients with a limited number of brain metastases [2,23,25,[28][29][30]. Whether SRS would demonstrate a survival advantage if only applied in TCC patients with few brain secondaries (up to three) in our institute, remains a speculation and a higher number of patients are required to clarify this issue.…”

Pre-operative stereotactic radiosurgery treatment is preferred to post-operative treatment for smaller solitary brain metastases

“…However, if the patient has stable systemic disease and brain metastases are well controlled, the survival is significantly improved. The prognosis of patients with a single brain metastasis appears to be much better than those with multiple metastases [18,19]. Therefore, treatment of such patients is often more aggressive and includes focal therapy, such as surgical resection or SRS in combination with WBRT.…”

Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing

“…Surgical resection may be used as the sole technique or in combination with WBRT after resection or SRT; SRS may be used on the surgical cavity after the resection. WBRT after the surgical resection decreases the risk of disease recurrence however this advantage doesn't project into overall survival benefit suggesting the possibility of deferring the WBRT, SRS or SRT for the time of disease recurrence (14)(15)(16)(17)(18). By contrast, SRT with WBRT compared with WBRT alone increases the overall survival of treated patients, indicating that these treatment modalities should be combined.…”