Steroid Effects on Neuronal Activity: When is the Genome Involved?

McEwen, Bruce S.; Coirini, Héctor; Schumacher, Michaël

doi:10.1002/9780470513989.ch2

Cited by 24 publications

(4 citation statements)

References 35 publications

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“…P can rapidly, in a non-genomic manner, influence anxiety via GABA A receptors [10], perhaps then over a longer period of time, P can influence anxiety through mechanisms that require PR. While the exact time course for genomic versus non-genomic action to occur is unclear, it is often agreed upon that genomic action can be measured in hours or days while non-genomic action can take place in seconds and/or minutes [45], [46]. Indeed, we have shown that systems regulated by P are only influenced by P after multiple days (3–5) of treatment [47].…”

Section: Discussionmentioning

confidence: 80%

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Auger

Forbes-Lorman

2008

PLoS ONE

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BackgroundIt is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone's anxiety reducing effects have solely been attributed to its rapid non-genomic effects at the GABAA receptor. This modulation occurs following the bioconversion of progesterone to allopregnanolone. Seemingly paradoxical results from some studies suggested that the function of progesterone to reduce anxiety-like behavior may not be entirely clear; therefore, we hypothesized that progesterone might also act upon progestin receptors to regulate anxiety.Methodology/Principal FindingsTo test this, we examined the anxiolytic-like effects of progesterone in male rats using the elevated plus maze, a validated test of anxiety, and the light/dark chamber in the presence or absence of a progestin receptor antagonist, RU 486. Here we present evidence suggesting that the anxiolytic-like effects of progesterone in male rats can be mediated, in part, by progestin receptors, as these effects are blocked by prior treatment with a progestin receptor antagonist.Conclusion/SignificanceThis indicates that progesterone can act upon progestin receptors to regulate anxiety-like behavior in the male rat brain.

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Section: Discussionmentioning

confidence: 80%

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Auger

Forbes-Lorman

2008

PLoS ONE

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“…Progesterone affects the function of the CNS in two fundamentally different ways [15]: a) one potential mechanism leads to structural or enzymatic changes that result from the interaction of the steroid with an intracellular receptor (as described previously) and subsequent activation of genomic regulated protein synthesis; b) the other mechanism may involve the interaction of 5α-pregnan-3α-ol-20-one (allopregnanolone), the ring A-reduced metabolite of progesterone, with GABA-A receptor-gated chloride ion (Cl -) channel [16]. This mechanism is related to the anxiolytic effects of progesterone.…”

Section: Effects Of Progesterone On the Central Nervous Systemmentioning

confidence: 99%

Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Andersen¹,

Bittencourt²,

Antunes

et al. 2006

CMC

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Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesity-hypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.

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“…These effects have differing temporal characteristics with nongenomic effects tending to be rapid in onset and of limited duration while genomic effects are generally slower in onset with a more prolonged duration. 25 In addition to differing cellular mechanisms of estrogens, there can be differences in sites of action. Bennett et al reported clear evidence of ERs on neuropeptide containing peripheral nervous system structures innervating the bladder 26 and central nervous system actions of estrogens were also reported.…”

Section: Discussionmentioning

confidence: 99%

Effect of Estrogen on Bladder Nociception in Rats

et al. 2010

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Purpose We assessed the effect of ovariectomy and estrogen replacement on nociceptive responses to bladder distention in a rat model. Materials and Methods Female Sprague-Dawley rats (Harlan™) underwent ovariectomy or sham surgery. Visceromotor responses (abdominal contractions) to bladder distention were determined 3 to 4 weeks later under isoflurane anesthesia. In rat subsets estrogen was chronically replaced with a subcutaneous estrogen pellet vs a placebo pellet or acutely replaced by subcutaneous injection 24 hours before testing. Effects of estrogen withdrawal were examined in another group of rats by implanting a pellet and explanting the pellet 24 hours before testing. Uterine weight was measured to assess the estrogen dose. Results Visceromotor responses to bladder distention were significantly less vigorous in ovariectomized rats vs controls. Acute estrogen replacement increased visceromotor responses in these rats but chronic estrogen replacement did not. Sudden chronic estrogen withdrawal resulted in increased visceromotor responses. Uterine weight was consistent with the physiological estrogen dose. Conclusions Estrogen alone was not sufficient to produce increased nociceptive responses but an acute decrease in estrogen resulted in increased visceromotor responses. These data suggest that the pronociceptive effects of estrogen may be due to a mismatch between peripheral vs central and/or genomic vs nongenomic effects of the hormone, which occur during rapidly decreasing estrogen levels.

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Steroid Effects on Neuronal Activity: When is the Genome Involved?

Cited by 24 publications

References 35 publications

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Effect of Estrogen on Bladder Nociception in Rats

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