Steroid receptor status and its clinicopathological correlation in post-menopausal breast cancer patients of Kumaon region of Uttarakhand

Abstract

The receptor positivity of steroid receptors was more in higher age groups, but the incidence of receptor positivity was lower than that reported in earlier studies. No statistically significant association was found between receptor status and clinical presentation of breast cancer, histopathological status of tumor and metastases.

Morphological profile and receptor status in breast carcinoma: An institutional study

“…Discordant findings in the study may be attributed to the race, as earlier reports were based on western population. [11] The proportion of breast carcinoma with HER2/neu overexpression is very low (2.4%), although not statistically significant, compared to 10 -34% HER2/neu positive breast carcinomas as reported earlier. [19] Thus the more aggressive breast carcinomas as reported do not appear to be due to HER2/neu overexpression.…”

“…Results in the study of histological grades of tumors and receptor status are in agreement with reports of earlier studies which have shown that poorly differentiated tumors are more common in receptor negative patients. [11] Similarly we found significant correlation between necrosis and HER-2/neu overexpression (P < 0.05).…”

“…Several studies have been reported related to examination of prognostic and predictive factors in breast cancer. [1,2,4,5,[9][10][11][12][13][14][15][16][17][18][19][20] With advancement in science and technology, new molecular methods are giving insight into biology of breast cancer and opening avenues for developing therapeutic strategies and predict the outcome. [21] In literature, HER-2/neu receptor overexpression is found to be an independent poor prognostic of tumor grade, tumor size and lymph node status.…”

Estrogen and progesterone receptor status in breast cancer: a cross-sectional study of 450 women in Kerala, South India

“…The average ERpositivity for white women in the US is 77% [8]. Studies done in India and in Indian emigrants have found ERpositivity in Indian women to be 34.5% [14], 35.88% [12], 37.83% [15], 38.6% [11], 49.2% [13], 50.5% [9], and 55.1% [16]. ERpositivity in premenopausal and postmenopausal women was found to be 56.1% and 47.4% respectively.…”