Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation

Toscano, Vincenzo; Balducci, R; Bianchi, Paola; Guglielmi, Rinaldo; Mangiantini, A; Sciarra, F

doi:10.1016/0960-0760(92)90081-s

Cited by 61 publications

(28 citation statements)

References 22 publications

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“…While TBP binding capacity could not be restored by hormonal treatment, EBP binding capacity increased almost to the level of the control group. These results are different from those obtained in mammals, where SSBPs are not affected by castration (von Shoultz and Carlstrom, 1989) and androgens seem to play an inhibitory action on SSBP levels in vivo (Toscano et al, 1992;Koritnik and Marschke, 1986;Kottler et al, 1988;). In the only other lower vertebrate studied so far, the trout, androgens do not affect SSBP plasma levels, a result also confirmed by in vitro observations (Foucher et al, 1991).…”

Section: Discussioncontrasting

confidence: 55%

“…Since SSBP are believed to be mainly synthesized in the liver (Mercier-Bodard et al, 1989), we can hypothesize a testosterone effect through its aromatization to 17β-estradiol. Indeed, estrogens have been reported to increase SSBP in human, heifer and trout (Toscano et al, 1992;Lermite and Terqui, 1991;Foucher et al, 1991), although they have little or not effect in monkeys (Koritnk and Marschke, 1986;Kottler et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

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Effect of 17β-Estradiol and Testosterone Treatment on Sex Steroid Binding Proteins in the Female of the Green Frog Rana esculenta

2000

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Effect of 17β-Estradiol and Testosterone Treatment on Sex Steroid Binding Proteins in the Female of the Green Frog Rana esculenta

2000

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“…Nevertheless, at present, SHBG regulation is considered as multifactorial and other non-steroidal factors seem to have an important role in the circulating levels of this binding protein (5,6). Now, there is much evidence that insulin may be an important modulator of SHBG concentrations.…”

Section: Introductionmentioning

confidence: 99%

Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children

Gascón

Valle

Martos

et al. 2000

European Journal of Endocrinology

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Objective: A relationship between hyperinsulinemia and decreased serum sex hormone-binding globulin (SHBG) has been described in adults. We evaluated the usefulness of SHBG as an index of hyperinsulinemia and/or insulin resistance in obese children (aged 6±9 years) of both sexes and its possible in¯uence on the androgenic status. Design: We carried out a cross-sectional study of cases and controls. We studied 61 obese children (22 males, 39 females) with body mass index (BMI) superior to the 90 th percentile and a control group of age-and sex-matched non-obese children. We measured serum glucose, insulin, TSH, free thyroxine, 17b-estradiol, testosterone and SHBG. Also, we correlated these parameters with anthropometric measures. Results: The obese group presented signi®cantly elevated levels of insulin (P 0:001) and insulin/ glucose ratio (P 0:0012) compared with the control group. SHBG (P 0:0001) and testosterone (P 0:0169) levels were signi®cantly lower than those in the non-obese group. We did not ®nd any difference in the free androgen index (FAI). Fasting insulin (r À0.4512; P < 0:001), BMI (r À0.3185; P < 0:05) and testosterone (r À0.3705; P < 0:01) were inversely correlated with SHBG concentration. According to multivariate analyses, insulin was the only independent predictor factor for serum SHBG concentration in the obese group (r partial=0.1280; P 0:0171). Conclusions: In summary, at this age there is a strong relationship between insulin and SHBG. The changes in SHBG levels of the obese group did not affect FAI and, therefore, they did not cause changes in the androgenic status. Our data support the role of insulin in the regulation of serum SHBG levels.

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“…Insulin has been shown to act as a growth factor for breast cancer (Pollak, 1998). There is also strong evidence that insulin is the central regulating factor for hepatic SHBG production (Toscano et al 1992) and has been shown to inhibit the production of SHBG in liver cells (Plymate et al 1990;Singh et al 1990). There is also relatively strong evidence that elevated plasma concentrations of insulin are related to lower SHBG levels in obese women (Franks et al 1991;Fendri et al 1994 Fig.…”

Section: Lipids Insulin and Breast Cancer Riskmentioning

confidence: 99%

Obesity, body fat distribution and breast cancer

Lovegrove

2002

Nutr. Res. Rev.

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Strong epidemiological data exists implicating anthropometric risk factors in breast cancer aetiology. In premenopausal women the risk of breast cancer increases with increased height, yet decreases with increasing weight and BMI. Although the evidence is not strong, a counter-intuitive positive relationship between central adiposity and premenopausal breast cancer risk is emerging. In post-menopausal women an increased risk in breast cancer has been found for all anthropometric measures: height, weight, BMI, measures of central adiposity (waist:hip ratio and waist circumference) and weight gain, with breast size being a possible additional risk factor. Weight loss as a strategy for reducing breast cancer risk seems to offer a viable prophylaxis in obese post-menopausal women, although data are limited. The evidence for anthropometric measures in relation to breast cancer risk is consistently stronger for post-menopausal women compared with premenopausal women and seems to be dependent on age. A number of possible biological mechanisms have been offered to explain the link between breast cancer risk and anthropometric measures. It has been hypothesised that obesity, especially central fat deposits, linked to insulin resistance, increases circulating hormones such as oestrogens, androgens, insulin, insulin-like growth factor-1 (IGF-1), and decreased levels of hormone-binding proteins such as steroid hormone-binding globulin and IGF-1 binding protein-1. Thus there are resulting increased concentrations of bioavailable sex hormones, which have been linked to increased breast cancer risk. As obesity is an important modifiable risk factor, which has been linked to increased post-menopausal breast cancer, public health recommendations to maintain ideal weight throughout life are warranted.

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Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation

Cited by 61 publications

References 22 publications

Effect of 17β-Estradiol and Testosterone Treatment on Sex Steroid Binding Proteins in the Female of the Green Frog Rana esculenta

Effect of 17β-Estradiol and Testosterone Treatment on Sex Steroid Binding Proteins in the Female of the Green Frog Rana esculenta

Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children

Obesity, body fat distribution and breast cancer

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