Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus

Lopez, Laureen M; Grimes, David A.; Schulz, Kenneth F.

doi:10.1002/14651858.cd006133.pub4

Cited by 32 publications

(21 citation statements)

References 76 publications

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“…Early studies in the general population have indicated that use of OCs, containing high ethynyl-oestradiol (EE) doses, can induce insulin resistance (IR) and hyperglycaemia and changes in the lipid profile [Kalkhoff, 1975;Phillips and Duffy, 1973]. However, follow-up studies demonstrated a limited effect on metabolic risk with no clinical significant repercussions when low doses of COCs were used [Gaspard et al 2003;Lopez et al 2007]. The strong association of PCOS with insulin resistance has raised concerns over the potential unfavorable effects of OCs on the metabolic aspects of the syndrome [Nader and Diamanti-Kandarakis, 2007].…”

Section: The Old Therapeutic Toolsmentioning

confidence: 99%

The effects of old, new and emerging medicines on metabolic aberrations in PCOS

Bargiota¹,

Diamanti-Kandarakis²

2012

Therapeutic Advances in Endocrinology

100

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age that is associated with significant adverse short-and long-term health consequences. Multiple metabolic aberrations, such as insulin resistance (IR) and hyperinsulinaemia, high incidence of impaired glucose tolerance, visceral obesity, inflammation and endothelial dysfunction, hypertension and dyslipidemia are associated with the syndrome. Assessing the metabolic aberrations and their long term health impact in women with PCOS is challenging and becomes more important as therapeutic interventions currently available for the management of PCOS are not fully able to deal with all these consequences. Current therapeutic management of PCOS has incorporated new treatments resulting from the better understanding of the pathophysiology of the syndrome. The aim of this review is to summarize the effect of old, new and emerging therapies used in the management of PCOS, on the metabolic aberrations of PCOS

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Section: The Old Therapeutic Toolsmentioning

confidence: 99%

The effects of old, new and emerging medicines on metabolic aberrations in PCOS

Bargiota¹,

Diamanti-Kandarakis²

2012

Therapeutic Advances in Endocrinology

100

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“…При выборе метода контрацепции боль-ные СД ориентируются на те же параметры, что здо-ровые женщины: контрацептивная эффективность метода и его безопасность. Прием КОК в стандарт-ном режиме у больных СД 1 типа без сосудистых осложнений также эффективен и безопасен, как у здоровых женщин [1][2][3][4][5]. В то же время исследова-ний, специально посвященных оценке эффектив-ности и безопасности пролонгированных режимов дозирования КОК у женщин с СД 1-го типа, нам найти не удалось.…”

Section: Discussionunclassified

“…Имеются сообщения о том, что комбинированные оральные контрацептивы (КОК) могут негативно сказываться на углеводном и липидном обмене. Од-нако данные, полученные в популяции здоровых женщин [2,3], а также выводы Кокрановского обзо-ра, посвященного оценке безопасности гормональ-ной контрацепции при СД, показывают, что низко-дозированные КОК практически не влияют на мета-болизм глюкозы и инсулинемию [4]. В соответствии с рекомендациями ВОЗ, обновленными в 2015 г., преимущества КОК превосходят возможные или до-казанные риски, связанные с их применением у больных СД 1 типа, т.е.…”

unclassified

The influence of extended regimen of hormone contraception in comparison with conventional regimen on carbohydrates metabolism and bleeding pattern in fertile women with diabetes mellitus type 1 (a pilot study)

Андреева¹,

Grigoryan²

2016

Probl. reprod.

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Влияние на углеводный обмен и анализ приемлемости (контроль менструального цикла) пролонгированных режимов гормональной контрацепции в сравнении со стандартным у женщин с сахарным диабетом 1 типа в репродуктивном периоде (пилотное исследование) Е Цель исследования -изучить эффективность, безопасность и переносимость пролонгированного режима приема КОК, содержащего 20 мкг этинилэстрадиола и 3 мг дроспиренона, у женщин, больных СД 1 типа. Материал и методы. В исследование включены 60 больных СД 1 типа с сохраненной репродуктивной способностью, по 30 пациенток в группе стандартного режима (24/4) и в группе пролонгированного режима (120/4) контрацепции. Продолжительность периода наблюдения от начала приема контрацептива 140 дней. Результаты. Показана высокая эффективность (отсутствие беременности к концу исследования) обеих схем, а также отсутствие влияния обоих режимов дозирования на углеводный и липидный обмен. Общая продолжительность кровотечений на фоне пролонгированной схемы уменьшалась, тогда как частота мажущих выделений была выше по сравнению со стандартной схемой. Выводы. Пролонгированная схема приема КОК эффективна и безопасна у женщин, больных СД 1 типа, при отсутствии противопоказаний для применения КОК. Необходимо проведение крупных длительных исследований для получения более обоснованных с научной точки зрения результатов. Objective -to study the efficacy, safety and tolerability of the extended regimen of COC containing ethinylestradiol 20 μg/ drospirenone 3 mg in patients with diabetes mellitus (DM). Мaterial and methods. Pilot study randomly (1:1) allocated 60 women (aged 18-40 years) with DM to the following regimens: conventional (24 days of active hormonal intake followed by a 4-day hormone-free interval) or fixed extended (120 days of uninterrupted active hormonal intake followed by 4-day tablet-free interval). Duration of active treatment phase was 140 days. Ключевые слова: сахарный диабет, репродуктивный период, контрацепция, дроспиренон, пролонгированный режим. The influence of extended regimen of hormone contraception in comparison withResults. High efficacy was demonstrated for both regimens. There was no negative influence of both regimens to carbohydrate and lipid metabolism. The general duration of bleeding/spotting days decreased whereas the number of spotting days increased in extended regimen in comparison to conventional regimen. The extended regimen of COC is effective and safe for DM type 1 women, who have no contraindication for this type of contraception.

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“…Diabetes is known to cause disorders in the glucose metabolism, impacting a series of metabolic processes, and eventually leading to multiple metabolic disorders (Garg et al, 2014;Lopez et al, 2014). The pentose phosphate pathway is a major pathway for glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular markers related to human alveolar bone cells and pathway analysis in diabetic patients

et al. 2015

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ABSTRACT. Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may facilitate the investigation of its mechanism. Alveolar bone osteoblasts isolated from 5 male diabetics and 5 male healthy adults were cultured. Total RNA was extracted from these cells and subjected to gene microarray analysis. Differentially expressed genes were screened, and a gene interaction network was constructed. An enrichment pathway analysis was simultaneously performed on differentially expressed genes to identify the biological pathways associated with changes in the alveolar bone cells of diabetic humans. In total, we identified 147 mRNAs that were differentially expressed in diabetic alveolar bone cells (than in the normal cells; 91 upregulated and 36 downregulated mRNAs). The constructed Diabetic alveolar bone cell microarray co-expression network showed 3 pairs of significantly-expressed genes. High-enrichment pathway analysis identified 8 pathways that were affected by changes in gene expression; three of the significant pathways were related to metabolism (inositol phosphate metabolism, propanoate metabolism, and pyruvate metabolism). Here, we identified a few potential genes and biological pathways for the diagnosis and treatment of alveolar bone cells in diabetic patients.

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Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus

Cited by 32 publications

References 76 publications

The effects of old, new and emerging medicines on metabolic aberrations in PCOS

The effects of old, new and emerging medicines on metabolic aberrations in PCOS

The influence of extended regimen of hormone contraception in comparison with conventional regimen on carbohydrates metabolism and bleeding pattern in fertile women with diabetes mellitus type 1 (a pilot study)

Identification of molecular markers related to human alveolar bone cells and pathway analysis in diabetic patients

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