Steroids: reactions and partial synthesis

Turner, A. B.

doi:10.1039/np9910800017

Cited by 9 publications

(2 citation statements)

References 83 publications

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“…Several cyanosteroids have been synthesized, including 3β-cyanosteroids such as 3-cyano-5-methoxy-5α-cholest-3-en-6-one (12), 3,5-dicyano-5α-cholest-3-en-6-one (13), as well as 5β-cyanosteroids like 5-cyano-5α-cholest-3-en-6-one (14) and (15). However, their biological activity remains unexplored [64].…”

Section: The Influence Of Nitrile Group(s) Positioning In Steroids An...mentioning

confidence: 99%

“…The first group comprises steroids with a nitro group in the second position (52)(53)(54)(55)(56)(57)(58)(59)(60)(61), as depicted in Figure 9, with their biological activity detailed in Table 3. The second group consists of anabolic steroids featuring a nitro group in the third position (62)(63)(64)(65)(66)(67)(68)(69)(70)(71). The third group encompasses steroids, with a nitro group in the fourth position (72)(73)(74)(75)(76)(77)(78)(79)(80)(81).…”

Section: Steroids Bearing Nitro Groupmentioning

confidence: 99%

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Steroids Bearing Heteroatom as Potential Drugs for Medicine

Dembitsky

2023

Biomedicines

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Heteroatom steroids, a diverse class of organic compounds, have attracted significant attention in the field of medicinal chemistry and drug discovery. The biological profiles of heteroatom steroids are of considerable interest to chemists, biologists, pharmacologists, and the pharmaceutical industry. These compounds have shown promise as potential therapeutic agents in the treatment of various diseases, such as cancer, infectious diseases, cardiovascular disorders, and neurodegenerative conditions. Moreover, the incorporation of heteroatoms has led to the development of targeted drug delivery systems, prodrugs, and other innovative pharmaceutical approaches. Heteroatom steroids represent a fascinating area of research, bridging the fields of organic chemistry, medicinal chemistry, and pharmacology. The exploration of their chemical diversity and biological activities holds promise for the discovery of novel drug candidates and the development of more effective and targeted treatments.

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Section: The Influence Of Nitrile Group(s) Positioning In Steroids An...mentioning

confidence: 99%

Section: Steroids Bearing Nitro Groupmentioning

confidence: 99%

Steroids Bearing Heteroatom as Potential Drugs for Medicine

Dembitsky

2023

Biomedicines

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Steroids

Morgan¹,

Moynihan²

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Steroids are members of a large class of lipid compounds called terpenes that are biogenically derived from the same parent compound, isoprene, C 5 H 8 . Steroids contain or are derived from the perhydro‐1,2‐cyclopentenophenanthrene ring system and are found in a variety of different marine, terrestrial, and synthetic sources. Nonhormonal steroids, eg, sterols and bile acids; vitamin D; and hormonal steroids, eg, the human sex hormones (androgens, estrogens, and progestins) and corticosteroids (glucocorticoids and mineralocorticoids) play critical roles in the physiology and biochemistry of most living creatures. Other naturally occurring steroids, such as plant steroids, marine steroids, ecdysteroids, cardiac steroids, steroid alkaloids, and steroid antibiotics, have a plethora of biological activities and uses. Many synthetic steroids are the product of pharmaceutical research that has resulted in the development of several steroid‐based medicines with a market value over $10 billion. Among the medicinally important synthetic steroids, are antihormones, anesthetics, antiinflammatories, antiasthmatics, contraceptive drugs, antibiotics, anticancer agents, cardiovascular agents, and osteoporosis drugs.

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