Sterols of the cucurbitaceae

Antitermite Activities of Coumarin Derivatives and Scopoletin from Protium javanicum Burm. f.

“…int. %): 412 (M + , 80), the 1 H-NMR and 13 C-NMR spectra were in good agreement with reported data (Farines et al 1981;Akihisa et al 1987). Fraction E9 (1.46 g) was subjected to CC on silica gel, eluted with n-hexane-EtOAc, and EtOAc-acetone (100:0 to 0:100) to obtain 6 sub fractions (E9a-E9f).…”

Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus‐1 reverse transcriptase

“…The 50% inhibitory concentration (IC 50 ) values were calculated by interpolation from the linear regression curve. Table 1 summarized the inhibitory effect against HIV-1 RT of 55 triterpenoids consisting of four cycloartanes (1-4), three lanostanes (5-7), three euphanes (8-10), two tirucallanes (11,12), six dammaranes (13)(14)(15)(16)(17)(18), one cucurbitane (19), eleven lupanes (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), seven oleananes (31)(32)(33)(34)(35)(36)(37), five ursanes (38)(39)(40)(41)(42), six multifloranes (43- (14), and ursolic acid (41; 6.4 µM) were shown to possess potent inhibitory effect against HIV-1 RT in this and in our recent studies (14), some synthetic derivatives of 25 (4,(16)(17)(18)(19)(20)(21), 32 (19), and 41 (22) have been reported to show strong anti-HIV-1 activity by inhibiting HIV-1 replication in H9 lymp...…”

Clionosterol and Ethyl Cholestan-22-enol Isolated from the Rhizome of <i>Polygala tenuifolia</i> Inhibit Phosphatidylinositol 3-Kinase/Akt Pathway

“…These isolated compounds were identified by instrumental analysis and compared to an authentic standard as reported in the literature. [14][15][16] Clionasterol (1) Live/Dead Assay of Tat-Expressing CHME5 Cell Line The previously established Tat-expressing CHME5 cells were used for this study. 5) Tat-expressing CHME5 cells were treated with 50 µg/mL LPS and 10 µg/mL CHX stress in the presence or absence of test agents.…”