Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

Fakoya, Adegbenro Omotuyi John; Omenyi, Princess; Anthony, Precious; Anthony, Favour; Etti, Precious; Otohinoyi, David Adeiza; Olunu, Esther

doi:10.3889/oamjms.2018.148

Cited by 45 publications

(62 citation statements)

References 75 publications

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“…SJS-TEN have been reported in various age groups but occurs more frequently in females, HIV-infected patients, and the elderly. Common causes include medications including antibiotics and antiepileptics and infections such as mycoplasma; however, 50% of cases remain idiopathic [2]. The increased incidence in the elderly population is likely due to increased medication usage with age [3].…”

Section: Introductionmentioning

confidence: 99%

“…In certain ethnic groups, medications like carbamazepine and allopurinol have a strong correlation with human leukocyte antigen-(HLA-) B * 1502 and HLA-B * 5801, respectively [4]. Unfortunately, the RegiSCAR study demonstrated that HLA-B * 1502 is not a confirmatory marker for any of the high-risk drugs known to cause SJS-TEN in Europeans; so, these HLA markers cannot be used to confirm the diagnosis [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome

Yin

Hadjokas

Mirchia

et al. 2020

Case Reports in Ophthalmological Medicine

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Purpose. To report an unusual presentation of commercial cannabidiol (CBD) oil-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis (SJS-TEN). Methods. A 56-year-old woman presented with acute onset of a diffuse, blistering, maculopapular rash with over 30% total body surface area (BSA) involvement two days after taking CBD oil sublingually for chronic pain. Biopsy confirmed SJS-TEN. Ophthalmology was consulted and mild eye involvement was found. She was started on topical cyclosporine, prednisone, moxifloxacin, and erythromycin ointment to prevent progression, which was successful. She was otherwise treated with supportive therapy in the intensive care burn unit and ultimately passed away from septic shock. Conclusion. In this case, we described an unusual drug-induced SJS from a commercial, non-FDA-regulated cannabis product. The use of a commercial CBD product should be cautioned due to potential for series of drug reactions to the cannabis product and the risk for reaction to other unregulated other pharmacological components.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome

Yin

Hadjokas

Mirchia

et al. 2020

Case Reports in Ophthalmological Medicine

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“…Stevens Johnson syndrome occurs in 1-2 million people per year [ 2 ]. Patients suffering from HIV, Hepatitis A, herpes simplex virus/varicella zoster virus (HSV/VZV) or autoimmune diseases, such as systemic lupus erythematosus, are more likely to experience SJS.…”

Section: Introductionmentioning

confidence: 99%

Stevens Johnson Syndrome Initiated by an Adverse Reaction to Trimethoprim-Sulfamethoxazole

Buganu¹,

Atta²,

Solomon³

et al. 2020

Cureus

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The authors present a case of a 54-year-old male who presented to the ED with Stevens Johnson syndrome (SJS) beginning on his upper lips, then spreading to his glans penis, airway, and buttocks. After using trimethoprim-sulfamethoxazole (TMP-SMX) to treat a pilonidal cyst diagnosed seven days prior to presentation, the patient began to have desquamating lesions on his upper and lower lips. Subsequently, he noticed desquamation on the glans penis and then between his buttocks. Before being referred to dermatology, he was treated with a high dosage of corticosteroids.

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“…In 1940, it was commonly called as Stevens-Johnson syndrome 1 . Stevens-Johnson syndrome is a serious dermatological condition with adverse hypersensitivity reactions that affect the skin and mucous membranes and are characterized by erythematous macules and hemorrhagic erosions of the mucous membranes and are triggered mainly by medications 2,3 .…”

Section: Introductionmentioning

confidence: 99%

A Case Report on Lamotrigine and Sodium Valproate Induced Stevens-Johnson Syndrome

Rai¹,

Bahuguna²,

Joshi³

et al. 2020

Int Res J Pharm

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Lamotrigine and Sodium valproate are the widely used drugs worldwide for treatment of generalized as well as partial seizures. They are very efficacious drugs. There is a very severe skin reaction associated with Lamotrigine when co-administered with Sodium valproate called Stevens -Johnson syndrome (SJS). A case of 15-year-old girl was presented to the hospital with high grade fever (on and off) with rashes and blisters all over the body and extremities as she was on Lamotrigine (LTG) and Sodium valproate combination therapy for episodes of seizures. The dose of both the drugs was high due to which she developed SJS. Patient was started on alternative anti-convulsant for treatment of seizures and symptomatic skin and eye care drug therapy was given to the patient to reduce skin and eye lesions due to SJS. Patients on drug therapy of Lamotrigine and Sodium valproate should be properly monitored and therapeutic drug monitoring as well as adverse effect reporting is further necessary.

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Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

Cited by 45 publications

References 75 publications

Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome

Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome

Stevens Johnson Syndrome Initiated by an Adverse Reaction to Trimethoprim-Sulfamethoxazole

A Case Report on Lamotrigine and Sodium Valproate Induced Stevens-Johnson Syndrome

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