Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review

Chattoraj, Sayantan; Daugherity, Patrick D.; McDermott, Todd S.; Olsofsky, Angela; Roth, Wyatt J.; Tobyn, Mike

doi:10.1016/j.xphs.2018.04.029

Cited by 52 publications

(26 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excessive lubrication is often needed to overcome tablets’ sticking, lamination, and capping. Furthermore, wearing of tableting tools, as a result of inappropriate compaction pressures, frequently occurs [ 14 ]. Due to the complex nature of the interaction between the formulation, compaction process, and the obtained tablets’ mechanical properties, it seems that sophisticated data-mining methods, such as machine-learning (ML) tools, are required for the appropriate interpretation of such phenomena.…”

Section: Introductionmentioning

confidence: 99%

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

Djuriš

Cirin-Varadjan²,

Aleksić

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.

show abstract

Section: Introductionmentioning

confidence: 99%

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

Djuriš

Cirin-Varadjan²,

Aleksić

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Enteric-coated (EC) hard capsules are frequently formulated as EC pellets or granules filled into uncoated capsule shells rather than having the filled capsule coated. However, EC capsules with enteric coating of the capsule shell are attractive in early drug development due to the ability to evaluate the performance of drugs that are available only in limited quantities because of the lower formulation effort (e.g., compared to a tablet) [3] or for drugs that are difficult to formulate as a tablet [4,5]. Furthermore, poorly water-soluble drugs or low-dose formulations might be encapsulated as liquid and semi-solid formulations to increase the intestinal absorption or provide a high content uniformity, respectively [6].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Enteric-Coated HPMC Capsules—Effect of Formulation Factors on Product Performance

Blechar

Sauer³

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the sealing performance of the capsule and the disintegration time were investigated. Furthermore, the influence of different disintegration test methods (with disc vs. without disc and 50 mM U.S. Pharmacopoeia (USP) buffer pH 6.8 vs. biopredictive 15 mM phosphate buffer pH 6.5) was evaluated. All formulations showed sufficient but not equivalent acid resistance when tested. Polymer type was the main factor influencing the capsule sealing and disintegration time. In addition, TEC and talc could affect the performance of the formulation. Regarding the choice of the disintegration test method, the presence of a disc had for the most part only limited influence on the results. The choice of disintegration buffer was found to be important in identifying differences between the formulations.

show abstract

“…These can severely decrease the tablet quality, yield, and productivity. [4][5][6] Till now, certain strategies have been used to resolve the problem of punch sticking of ETs that occurs during compaction. Traditionally, several water-soluble lubricants (like macrogol 6000) are oen added in ETs, which can disperse on the surfaces of steel and/or effervescent granules to decrease their contact during tableting and therefore reduce the risk of sticking.…”

Section: Introductionmentioning

confidence: 99%

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Zheng

Yang

et al. 2019

RSC Adv.

View full text Add to dashboard Cite

show abstract

Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review

Cited by 52 publications

References 138 publications

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

In Vitro Evaluation of Enteric-Coated HPMC Capsules—Effect of Formulation Factors on Product Performance

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Contact Info

Product

Resources

About