Stiffened and toughened polyacrylamide/polyanionic cellulose physical hydrogels mediated by ferric ions

Wang, Jianquan; Ma, Ying; Dai, Xiaofu; Gong, Baixue; Chen, Pan; Shao, Ziqiang; Huang, Xiaonan

doi:10.1007/s00396-021-04823-8

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…The redshift of the amide II absorption bands of Gel/Zr and Gel/Zr/EGCG5.0 hydrogel compared with that of Gel (1531.3 cm −1 ) confirmed the formation of coordination bonds between Gel and the metal ions. [ 29 , 30 ] When Zr 4+ coordinates with Gel, it rearranges the triple‐helix‐like structure of Gel, hydrogen bonding in Gel becomes easier to form. The carbonyl stretching vibrational peak of Gel at 1639.8 cm −1 and the Gel/Zr redshift to 1628.2 cm −1 confirms that the hydrogen bonding of Gel is strengthened.…”

Section: Resultsmentioning

confidence: 99%

Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

Zan,

Yang,

Xiao

et al. 2023

Advanced Science

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Treating the most widespread complication of diabetes: diabetic wounds poses a significant clinical obstacle due to the intricate nature of wound healing in individuals with diabetes. Here a novel approach is proposed using easily applicable injectable gelatin/metal/tea polyphenol double nanonetworks, which effectively remodel the wound microenvironment and accelerates the healing process. The gelatin(Gel) crosslink with metal ions (Zr4+) through the amino acids, imparting advantageous mechanical properties like self‐healing, injectability, and adhesion. The nanonetwork's biological functions are further enhanced by incorporating the tea polyphenol metal nanonetwork through in situ doping of the epigallocatechin gallate (EGCG) with great antibacterial, self‐healing, antioxidant, and anticancer capabilities. The in vitro and in vivo tests show that this double nanonetworks hydrogel exhibits faster cell migration and favorable anti‐inflammatory and antioxidant properties and can greatly reshape the microenvironment of diabetic wounds and accelerate the wound healing rate. In addition, this hydrogel is completely degraded after subcutaneous injection for 7 days, with nondetectable cytotoxicity in H&E staining of major mice organs and the serum level of liver function indicators. Considering the above‐mentioned merits of this hydrogel, it is believed that the injectable gelatin/metal/tea polyphenol double nanonetworks have broad biomedical potential, especially in diabetic wound repair and tissue engineering.

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Section: Resultsmentioning

confidence: 99%