Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension

Chen, Ju Yi; Tsai, Wei Chuan; Lin, Chao-Cheng; Huang, Yao Yi; Hsu, Chih Hsin; Liu, Ping Yen; Chen, Jyh Hong

doi:10.1080/08037050510034301

Cited by 28 publications

(22 citation statements)

References 22 publications

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“…Among the healthy subjects, Millasseau et al (2002) found that SI DVP correlated to PWV (r=0.65). Another study by Chen et al (2005) observed that among hypertensive subjects, SI DVP correlated to aortic SI (r=0.31) and distensibility (r=-0.34) measured via echocardiogram. Study by Woodman et al (2003) found that SI DVP correlated to PWV (r=0.54).…”

Section: Discussionmentioning

confidence: 92%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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ABSTRAK Dua petanda kesihatan salur darah baru yang dihasilkan daripada gelombang fotopletismografi jari (PPG) telah diperkenalkan berdasarkan populasi rakyat Malaysia iaitu indeks kecergasan PPG (PPGF) dan indeks jangkaan risiko salur darah (VRPI). Antara objektif kajian ini adalah untuk mengkaji hubungan antara PPGF dengan petanda penyakit jantung (CVD (Beta = 0.35, p < 0.01), p < 0.01), p = 0.04) dan ketinggian (Beta = 0.24, p < 0.01 ABSTRACTTwo new vascular health markers which are derived from finger photoplethysmography (PPG) waveform have been introduced based on Malaysian population, namely PPG fitness index (PPGF) and vascular risk prediction index (VRPI). The objectives of this study were to investigate the associations between PPGF and other cardiovascular disease (CVD) markers such as carotid femoral pulse wave velocity (PWV CF ), to compare PPGF between those with and without CVD risk factors and to determine the sensitivity of VRPI in identifying young subjects with CVD risk factors. A total of 114 men age 20 to 40 yrs with and without CVD risk factors were recruited. Risk factors included hypertension, smoking, dyslipidemia, abdominal obesity and family history of premature CVD. Subjects were divided into healthy, those with one risk factor and those with at least two risk factors. Their weight, height, peripheral and central blood pressure (BP), PWV CF and PPGF were measured and the sensitivity of VRPI in predicting subjects with CVD risk factor was calculated. Data was analyzed via SPSS version 15 and p < 0.05 was considered significant. The mean age of the subjects was 28.94 ± 4.86 yrs. No differences in PPGF was observed between groups (p > 0.05). The independent variables for PPGF were forward pressure (Beta = 0.35, p < 0.01), PWV CF (Beta = -0.26, p < 0.01), systolic BP (Beta = -0.26, p = 0.04) and height (Beta = 0.24, p < 0.01). The sensitivity of VRPI was 82.02%. In conclusion, PPGF was correlated to PWV CF and may be a potential marker of arterial stiffness. In addition, VRPI is sensitive to be used as an early screening of CVD risk factors.

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Section: Discussionmentioning

confidence: 92%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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“…The usefulness of the SI DVP as a noninvasive alternative to detect arterial stiffness was also successfully tested in patients with hypertension, diabetes mellitus and children [36,54,55] . Furthermore, SI DVP can help in the risk stratification of both hypertensive and apparently healthy people with different CV risk factors [56,57] .…”

Section: Discussionmentioning

confidence: 99%

Different Effect of IgA Nephropathy and Polycystic Kidney Disease on Arterial Stiffness

Késői¹,

Sági²,

Tóth³

et al. 2011

Kidney Blood Press Res

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Background: Renal function is a major predictor of vascular function and cardiovascular diseases. Little information exists about the effect of specific renal diseases on vascular function in chronic kidney diseases (CKD). Methods: One hundred and twenty patients (60 with IgA nephropathy, IgAN, and 60 with polycystic kidney disease, PKD) with CKD stages 1–4 were studied and compared. Pulse-wave velocity was measured by the digital volume pulse (DVP) method and stiffness index (SI_DVP) was derived. Results: All CKD (IgAN and PKD) patients had increased SI_DVP compared to controls (10.39 vs. 8.87 ± 1.79 m/s, p = 0.008). PKD patients had increased SI_DVP compared to IgAN and controls (11.14 ± 2.19, 9.66 ± 2.02 and 8.87 ± 1.79 m/s, respectively, p < 0.001). An inverse correlation was found between SI_DVP and glomerular filtration rate in all CKD (IgAN and PKD) patients (p = 0.001) and in IgAN alone (p < 0.01), but not in PKD. With multivariate regression analysis, only age and 24-hour systolic blood pressure exerted independent effects on SI_DVP. Conclusions: Compared to controls, arterial stiffness was increased in CKD patients. However, arterial stiffening was more pronounced in PKD than in IgAN, suggesting that vascular function is not similarly altered in etiologically different CKD groups. The fact that blood pressure was an independent risk factor underscores a therapeutic opportunity.

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“…Although no differences in age and HR were found, the mean BP was different between groups (Table VI in the online-only Data Supplement). Two arterial stiffness indices, stiffness index and compliance index, 20,21 were measured. Obese and overweight subjects showed trends toward higher stiffness index than normal weight subjects ( Figure 6C).…”

Section: Arterial Stiffening and Lower Lox Levels In Obese Humansmentioning

confidence: 99%

Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity

Chen¹,

Tsai²,

Tai

et al. 2013

ATVB

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Objective-One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening. Approach and Results-Obese (ob/ob) mice were used to examine physical, morphological, and molecular changes in the aorta in response to obesity. ob/ob mice had increased aortic pulse wave velocity and tissue rigidity. ob/ob aorta exhibited decreases of lysyl oxidase (LOX) activity and cross-linked elastin, and increases of elastin fragmentation and elastolytic activity. The aortas of ob/ob mice were surrounded by a significant amount of proinflammatory and pro-oxidative perivascular adipose tissue. In vitro studies revealed that the conditioned medium from differentiated adipocytes or the perivascular adipose tissue of ob/ob mice attenuated LOX activity. Furthermore, inhibition of LOX in wild-type lean mice caused elastin fragmentation and induced a significant increase in pulse wave velocity. Finally, we found that obese humans had stiffer arteries and lower serum LOX levels than do normal-weight humans. Conclusion-Our results demonstrated that obesity resulted in aortic stiffening in both humans and mice, and established a causal relationship between LOX downregulation and aortic stiffening in obesity.

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Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension

Cited by 28 publications

References 22 publications

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Different Effect of IgA Nephropathy and Polycystic Kidney Disease on Arterial Stiffness

Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity

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