Stiffness parameters, intima-media thickness and early atherosclerosis in systemic lupus erythematosus patients

Cacciapaglia, Fabio; Em, Zardi; Coppolino, G.; Buzzulini, Francesca; Margiotta, Domenico Paolo Emanuele; Arcarese, Luisa; Vadacca, Marta; Amoroso, Antonio; Afeltra, Antonella

doi:10.1177/0961203308097571

Cited by 45 publications

(27 citation statements)

References 45 publications

(50 reference statements)

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“…This mirrors findings in two other large US SLE cohort studies in which cross-sectional IMT2 and IMT progression45 did not differ between SLE and controls. In contrast, several smaller European and US studies do demonstrate higher IMT in SLE 42 46–48. Again, this discrepancy in our cohort might be due to the exclusion of statins.…”

Section: Discussioncontrasting

confidence: 93%

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

McMahon

Skaggs

Sahakian

et al. 2011

Annals of the Rheumatic Diseases

141

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BackgroundPatients with systemic lupus erythematosus (SLE) are at increased risk of atherosclerosis, even after accounting for traditional risk factors. High levels of leptin and low levels of adiponectin are associated with both atherosclerosis and immunomodulatory functions in the general population.ObjectiveTo examine the association between these adipokines and subclinical atherosclerosis in SLE, and also with other known inflammatory biomarkers of atherosclerosis.MethodsCarotid ultrasonography was performed in 250 women with SLE and 122 controls. Plasma leptin and adiponectin levels were measured. Lipoprotein a (Lp(a)), oxidised phospholipids on apoB100 (OxPL/apoB100), paraoxonase, apoA-1 and inflammatory high-density lipoprotein (HDL) function were also assessed.ResultsLeptin levels were significantly higher in patients with SLE than in controls (23.7±28.0 vs 13.3±12.9 ng/ml, p<0.001). Leptin was also higher in the 43 patients with SLE with plaque than without plaque (36.4±32.3 vs 20.9±26.4 ng/ml, p=0.002). After multivariate analysis, the only significant factors associated with plaque in SLE were leptin levels in the highest quartile (≥29.5 ng/ml) (OR=2.8, p=0.03), proinflammatory HDL (piHDL) (OR=12.8, p<0.001), age (OR=1.1, p<0.001), tobacco use (OR=7.7, p=0.03) and hypertension (OR=3.0, p=0.01). Adiponectin levels were not significantly associated with plaque in our cohort. A significant correlation between leptin and piHDL function (p<0.001), Lp(a) (p=0.01) and OxPL/apoB100 (p=0.02) was also present.ConclusionsHigh leptin levels greatly increase the risk of subclinical atherosclerosis in SLE, and are also associated with an increase in inflammatory biomarkers of atherosclerosis such as piHDL, Lp(a) and OxPL/apoB100. High leptin levels may help to identify patients with SLE at risk of atherosclerosis.

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Section: Discussioncontrasting

confidence: 93%

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

McMahon

Skaggs

Sahakian

et al. 2011

Annals of the Rheumatic Diseases

141

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“…Furthermore, our results was in accordance with the study of Cacciapaglia et al 24 where IMT in patients with SLE significantly correlated with disease duration, and SLEDAI. However, our results differed from theirs since, in our study, there was no statistically significant relation between disease duration and carotid IMT.…”

Section: Discussionsupporting

confidence: 83%

Microparticles (CD146) and Arterial Stiffness Versus Carotid Intima Media Thickness as an Early Predictors of Vascular Affection in Systemic Lupus Patients

et al. 2016

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Objectives: This study aims to evaluate cluster of differentiation 146 (CD146) and pulse wave velocity (PWV) as non-invasive methods for prediction of early vascular affection in systemic lupus erythematosus (SLE) patients without symptoms of vascular disease, to detect the outcome and reproducibility of these methods, and to correlate CD146 and PWV with lipid profile, intima media thickness (IMT), and ankle brachial index. Patients and methods: Thirty female SLE patients (mean age 26.6±6.6 years; range 15 to 35 years) fulfilling the American College of Rheumatology 1997 revised criteria for SLE classification, and 15 age and sex matched healthy controls were included. All participants were performed full clinical assessments including measurement of Systemic Lupus Erythematosus Disease Activity Index, lipid profile, CD146, carotid IMT, PWV, and rise time as an indication of how fast the waveform rises. Results: Cluster of differentiation 146 levels were elevated in patients with SLE compared to controls (p<0.001). There was a statistically significant difference between patients and controls in the femoral, lower thigh, and ankle rise time. There was a statistically significant correlation between IMT and ages of patients, Systemic Lupus Erythematosus Disease Activity Index, and brachial-below knee PWV, while there was no correlation between IMT and disease duration, lipid profile, brachial-femoral PWV, and brachial-ankle PWV. There was statistically significant correlations between brachial-femoral PWV and serum cholesterol level, and between brachial-ankle PWV and low density lipoprotein cholesterol. Conclusion: Our results showed that SLE vascular affection is more pronounced in small arteries. Also, elevated CD146 and brachial-femoral PWV are useful early markers of vascular affection in SLE as well as rise time may be a marker for arterial stiffness.

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“…For several years, assessment ofatherosclerosis in connective tissue diseases has been gaining interest in rheumatology research, due to the growing evidence of a link between chronic inflammatory rheumatic diseases and atherosclerosis (1)(2)(3)(4)(5)(6)(7)(8).…”

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confidence: 99%

Subclinical Carotid Atherosclerosis in Elderly Patients with Primary Sjögren Syndrome: A Duplex Doppler Sonographic Study

Zardi

Sambataro

Basta

et al. 2014

Int J Immunopathol Pharmacol

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A growing body of evidence presents a link between chronic inflammatory rheumatic diseases and atherosclerosis. Toevaluate subclinical carotid atherosclerosis in an elderly group of patients with primary Sjogren syndrome compared with a control group matched for age, sex, ethnicity and cardiovascular risk factors, we enrolled 18 patients with Primary Sjogren Syndrome (mean age 65±5.93 SD) and 18 mild Ostheoarthritic patients (mean age 66±5.94 SD) from the outpatient department of Rheumatology, University "Campus Bio-Medico, Rome, Italy, matched for age, sex, ethnicity and cardiovascular risk factors. A duplex Doppler sonographic study of carotids was performed in order to evaluate intimamedia thickness (IMT), stiffness and haemodynamic parameters [resistivity and pulsatility indices (RI and PI, respectively)]. No significant difference was found between primary Sjogren syndrome and control patients in IMT, stiffness and haemodynamic parameters. The lack of significant difference in subclinical atherosclerosis between elderly primary Sjogren syndrome and control matched patients, indicates that traditional cardiovascular risk factors, immunologic alterations and chronic inflammation do not influence the progression of vascular damage in the carotid circulation of patients with median disease duration of 6.5 years.

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Stiffness parameters, intima-media thickness and early atherosclerosis in systemic lupus erythematosus patients

Cited by 45 publications

References 45 publications

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

Microparticles (CD146) and Arterial Stiffness Versus Carotid Intima Media Thickness as an Early Predictors of Vascular Affection in Systemic Lupus Patients

Subclinical Carotid Atherosclerosis in Elderly Patients with Primary Sjögren Syndrome: A Duplex Doppler Sonographic Study

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