Stigmastane derivatives and isovaleryl sucrose esters from Vernonia guineensis (Asteraceae)

Tchinda, Alembert T.; Tane, Pierre; Ayafor, J. Foyere; Connolly, Joseph D.

doi:10.1016/s0031-9422(03)00326-1

Cited by 29 publications

(23 citation statements)

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“…In addition, phytochemical studies have reported the presence of compounds, such as flavonoids, steroids and polysaccharides, which contribute to the anti-inflammatory and immunomodulating activity of some medicinal plants from the genus Vernonia (Huang et al, 2003;Tchinda et al, 2003;Nergard et al, 2004). These compounds may act in several inflammatory pathways or interact with mediators involved in the inflammatory response, such as arachidonic acid metabolites, cytokines, nitric oxide, cyclooxigenase-2, phospholipase A 2 , nuclear factor-B and others (Calixto et al, 2003), making the plants of Asteraceae family promising as a new therapy for inflammatory skin conditions.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

Rauh

Horinouchi

Loddi

et al. 2011

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

Rauh

Horinouchi

Loddi

et al. 2011

Journal of Ethnopharmacology

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“…Some other compounds have been isolated from Vernonia, such as flavonoids (18), steroids (19) and polysaccharides (20).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Pagno

Blind

Biavatti

et al. 2006

Braz J Med Biol Res

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Vernonia scorpioides has been widely used in Brazil to treat skin problems and chronic wounds, such as ulcers of the lower limbs and diabetic lesions. In the present study, we investigated the effect of a dichloromethane (DCM) fraction of V. scorpioides leaf extract on Ehrlich ascitic and solid tumor-bearing mice. The animals were treated once a day with the DCM fraction at a concentration of 5 mg/kg, administered ip during and after the development of the tumor. The lifespan, weight, number and type of leukocytes, number of tumor cells, volume of solid and ascitic tumors were measured. The development of the tumor with pre-treated tumor cells in vitro with the DCM fraction (5 mg/kg) was analyzed and the animals were sacrificed after 7 days. The DCM fraction (5 mg/kg) totally inhibited tumor development when in direct contact with tumor cells, and also ascitic tumor development with in vitro treatment or when administered ip, in loco (after 7 days). Animals treated with the DCM fraction increased their lifespan ca. 2 weeks and maintained their body weight for 30 days. When applied immediately after the inoculation of the tumor cells in vivo, it totally abolished tumor development, with tumor development only decreasing when treatment was started 3 days after the tumor challenge. These data suggest an antineoplastic activity of the fraction. Oral or ip administration of DCM fraction (5 mg/kg) for 7 days did not reduce the solid tumor volume. The cytotoxic activity described here differs from the conventional immune suppressing profile of standard chemotherapy because it increases neutrophil influx to the peritoneal cavity. These results show that, besides exhibiting a tumoricidal activity, the DCM fraction also exhibits inflammatory activity.

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“…[31][32][33] In current study, eight isovaleryl sucrose esters were obtained from the whole plants of A. yunnanensis. It is the rst report of poly isovaleryl sucrose derivatives from Ainsliaea species.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic isovaleryl sucrose esters from Ainsliaea yunnanensis: reduction of mitochondrial membrane potential and increase of reactive oxygen species levels in A549 cells

Fang

Zhuo

et al. 2017

RSC Adv.

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Eight isovaleryl sucrose esters, named ainslosides A-H (1-8), were isolated from Ainsliaea yunnanensis Franch. Their structures, including the absolute configurations of the sugar residues, were elucidated by extensive analysis of NMR spectra and acid hydrolysis. All compounds were tested in vitro for cytotoxicity against four human tumour cell lines, A549, HCT116, MDA-MB-231, and BEL7404. Among the compounds tested, ainsloside B (2) showed potent cytotoxicity against the A549 cell line with an IC 50 value of 3.3 mM. Flow cytometry analysis showed that compound 2 can arrest the cell cycle at the G 0 /G 1 phase and induce cell apoptosis in A549 cells. Further studies indicated that the apoptosis-inducing effect of compound 2 may be involved in the reduction of mitochondrial membrane potential (MMP) and increase of reactive oxygen species (ROS) level in A549 cells.

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Stigmastane derivatives and isovaleryl sucrose esters from Vernonia guineensis (Asteraceae)

Cited by 29 publications

References 10 publications

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Cytotoxic isovaleryl sucrose esters from Ainsliaea yunnanensis: reduction of mitochondrial membrane potential and increase of reactive oxygen species levels in A549 cells

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