Stilbene dimers from the lianas of Gnetum hainanense

Huang, Kuan‐Tsae; Wang, Yinghong; Li, Rongli; Lin, Mao Tsun

doi:10.1016/s0031-9422(00)00151-5

Cited by 62 publications

(52 citation statements)

References 8 publications

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“…Gnetum cleistostachyum, a Chinese herb that grows in the YunNan province of Southwestern of China, has been used for treatment of arthritis, bronchitis, cardiovascular system disease, and several cancers including bladder cancer for hundreds of years (1). ISO is a new derivative of stilbene, recently isolated from the Gnetum cleistostachyum (2).…”

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confidence: 99%

“…It was accepted that * This work was supported, in whole or in part, by National Institutes of Health Grants CA112557 from the NCI, ES000260 and ES010344 from the NIEHS, and National Science Foundation Grants NSFC81229002 and NSFC30971516. 1 To whom correspondence should be addressed: 57 Old Forge Rd., Tuxedo, NY 10987. XIAP overexpression in cancer tissues is associated with cancer progression, metastasis, and resistance to cancer therapy such as immunotherapy, chemotherapy, and radiotherapy (8).…”

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confidence: 99%

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The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP

Fang

Hou

et al. 2012

Journal of Biological Chemistry

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Background:The anti-cancer activity and mechanisms of isorhapontigenin (ISO) have never been explored. Results: ISO exhibited an anti-cancer activity accompanied by apoptotic induction and XIAP down-regulation through attenuation of SP1 expression. Conclusion: ISO is an active anti-cancer compound by inducing apoptosis via down-regulation of SP1/XIAP pathway. Significance: Current studies identify a new promising active compound for therapy of human cancers with XIAP overexpression.

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confidence: 99%

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confidence: 99%

The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP

Fang

Hou

et al. 2012

Journal of Biological Chemistry

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“…However, only a few of them that had been studied and proved benefits also the mechanism of action scientifically. Medicinal plants and vegetables provide stilbene with the interesting biological activity including apoptosis induction of colon cancer [2] and blood glucose reduction [3]. One of stilbene derivates, resveratrol which was known to provide anti-aging activity [4], antidiabetic, cardioprotective, anticancer [5], antioxidant [6], anti-inflammatory, and antithrombotic [7] so that many studies had been conducted to find the other possible potential effect which could benefit human life.…”

Section: Introductionmentioning

confidence: 99%

“…Genus Gnetum (Gnetaceae family) has been known to contains stilbene, such as resveratrol, in high concentration [3,8,9]. One of those plants is Gnetum gnemon L. or locally known as Melinjo, which widely cultivated in Southeast Asia.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

Mun’im

Munadhil²,

Puspitasari³

et al. 2017

Asian J Pharm Clin Res

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Objectives: To evaluate the angiotensin converting enzyme (ACE) inhibitory activity of melinjo (Gnetum gnemon) seed extract and to study molecular docking of stilbene contained in melinjo seeds. Methods:Melinjo seed powders were extracted with n-hexane, dichloromethane, ethyl acetate, methanol, and water successively. The extracts were evaluated ACE inhibitory activities using ACE kit-Wist and the phenolic content using Folin-Ciocalteu method. The extract demonstrated the highest ACE inhibitory activity was subjected to liquid chromatography-mass spectrometry (LC-MS) to know its stilbene constituent. The stilbene constituents in melinjo seed were performed molecular docking using AutoDock Vina, and ligand-receptor Interactions were processed using Ligand Scout. Results:The ethyl acetate extract demonstrated the highest ACE inhibition activity with inhibitory concentration 50% value of 9.77 × 10 −8 μg/mL and the highest total phenolic content (575.9 mg gallic acid equivalent/g). Ultra-performance LC-MS analysis of ethyl acetate extract has detected the existency of resveratrol, gnetin C, ε-viniferin, and gnemonoside A/B. These compounds displayed similar physiochemical properties to lisinopril (ACE inhibitor), as in silico molecular docking studies demonstrated that they fit into the lisinopril receptors. Conclusion:In vitro analysis ethyl acetate extract from melinjo seeds demonstrated the highest ACE inhibitory activity. Molecular docking analysis indicated that resveratrol dimers, gnetin C and gnemonoside A can be considered ACE inhibitor.

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“…Oxyresveratrol has been detected, extracted and/or isolated from Artocarpus lakoocha Roxburgh (Moraceae) (Chuanasa et al, 2008;Likhitwitayawuid et al, 2006), Artocarpus dadah Maneechai et al, 2009), Artocarpus heterophyllus (Fang et al, 2008), Smilax china (Huang et al, 2008), Morus alba L. (mulberry wood) (Breuer et al, 2006;Oh et al, 2002), Morus macroura (Syah et al, 2000), Gnetum hainanense (Huang et al, 2000), Melaleuca leucadendron (Tsuruga et al, 1991), and Schoenocaulon offi cinale A Gray ex Benth. (Liliaceae) (Kanchanapoom et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatographic analysis: applications to nutraceutical content and urinary disposition of oxyresveratrol in rats

Bertram¹,

Takemoto²,

Remsberg³

et al. 2009

Biomedical Chromatography

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A high-performance liquid chromatographic (HPLC) method was developed for the analysis of the stilbene, oxyresveratrol. This method involves the use of a Luna C(18) column with ultraviolet detection at 320 nm. The mobile phase consisted of acetonitrile, water and formic acid (30 : 70 : 0.04 v/v) with a flow rate of 0.6 mL/min. The calibration curves were linear over the range of 0.5-100.0 microg/mL. The mean extraction efficiency was between 98.9 and 109%. The precision of the assay was 0.069-18.4% (RSD%), and within 20% at the limit of quantitation (0.5 microg/mL). The bias of the assay was <15% and within 15% at the limit of quantitation. This assay was successfully applied to pre-clinical pharmacokinetic samples from rat urine and to nutraceutical product analysis.

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Stilbene dimers from the lianas of Gnetum hainanense

Cited by 62 publications

References 8 publications

The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP

The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP

Angiotensin Converting Enzyme Inhibitory Activity of Melinjo (Gnetum Gnemon L.) Seed Extracts and Molecular Docking of Its Stilbene Constituents

High‐performance liquid chromatographic analysis: applications to nutraceutical content and urinary disposition of oxyresveratrol in rats

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