Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review

Teka, Tekleab; Lele, Zhang; Ge, Xianping; Li, Yanjie; Han, Lifeng; Yan, Xiaohui

doi:10.1016/j.phytochem.2022.113128

Cited by 90 publications

(81 citation statements)

References 312 publications

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“…In contrast, white wines have, on average, a six times lower concentration of trans -resveratrol [ 10 ]. Other natural sources are pistachios, peanuts, blueberries, raw cranberry juice, chocolate, strawberries, cocoa and red currants [ 11 , 12 ]. Interestingly, the trans -resveratrol glycoside content was analyzed in several parts of the plant popularly called Japanese knotweed or Itadori plant ( Polygonum cuspidatum Sieb et Zucc): young stem (497 μg/g) vs. old stem (83 μg/g), young leaf (867 μg/g) vs. old leaf (370 μg/g) and commercial root (1653 μg/g).…”

Section: The Occurrence and Sources Of Resveratrolmentioning

confidence: 99%

Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

et al. 2022

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Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stability and bioavailability. To overcome this problem, researchers started to design and create different delivery systems that could improve the delivery amount of Rv. Therefore, this review aims to shed light on the proper and efficient techniques to isolate, purify and quantify the Rv molecule, and how this therapeutic molecule can be a part of a delivery system. The Rv great impact on aspects regarding its stability, bioavailability and absorption are also debated here, based on the existent literature on in vitro and in vivo human and animal studies. Moreover, after its absorption the Rv influence at the molecular level in ocular pathologies is described. In addition, the present review summarizes the available literature about Rv, hoping that Rv will gain more attention to investigate its unexplored side.

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Section: The Occurrence and Sources Of Resveratrolmentioning

confidence: 99%

Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

et al. 2022

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“…The basic chemical structure of stilbenes consists of a C6-C2-C6 skeleton, usually with two isomeric forms. [ 37 ]. Resveratrol, from grapes and red wine, is one of the best-studied stilbenes [ 38 ].…”

Section: Polyphenol: Chemistry and Biological Functionmentioning

confidence: 99%

Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models

Tain

Hsu

2022

IJMS

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Polyphenols are the largest group of phytochemicals with health benefits. Early life appears to offer a critical window of opportunity for launching interventions focused on preventing hypertension, as increasing evidence supports the supposition that hypertension can originate in early life. Although polyphenols have antihypertensive actions, knowledge of the potential beneficial action of the early use of polyphenols to avert the development of hypertension is limited. Thus, in this review, we first provide a brief summary of the chemistry and biological function of polyphenols. Then, we present the current epidemiological and experimental evidence supporting the early-life origins of hypertension. We also document animal data on the use of specific polyphenols as an early-life intervention to protect offspring against hypertension in adulthood and discuss underlying mechanisms. Continued research into the use of polyphenols to prevent hypertension from starting early in life will have far-reaching implications for future health.

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“…A very recent review delineates the wide plant sources from where they are originated, the pharmacological signifi- cances seen over decades and problems that needs to be surmounted before their clinical applications. [106] The most common dietary stilbenes 96-107 a,78 and 80 are presented in Figure 24.…”

Section: Stilbenes Dihydrostilbenes and Their Glycosidesmentioning

confidence: 99%

“…As pterostilbene 103 and resveratrol 97 are at the crossroads of finding evidence from human‐based in vivo and in vitro studies, the synthesis of hybrid stilbene derivatives can improve the bioavailability problem of these promising compounds [106a] …”

Section: Stilbenes Dihydrostilbenes and Their Glycosidesmentioning

confidence: 99%