Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz.

Lee, J.-C.; Lee, K.-Y.; Son, Young‐Ok; Choi, Ki-Seok; Kim, J.; Kim, S.-H.; Chung, Gook-Hyun; Jang, Yong-Suk

doi:10.1016/j.phymed.2006.09.012

Cited by 51 publications

(28 citation statements)

References 8 publications

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“…IL-2 is a cytokine produced by activated T cells that has shown powerful immunostimulatory and antineoplastic properties (Lee et al, 2005). Previous in vivo and in vitro results have shown that baizhu could promote ConA and LPSinduced splenocyte and peripheral lymphocyte proliferation (Lee et al, 2007). The underlying mechanisms are largely unknown, however.…”

Section: Discussionmentioning

confidence: 99%

“…The rhizomes of Atractylodes macrocephala Koidz are rich in sesquiterpenes, acetylenic, polysaccharides, and glycoproteins (Lee et al, 2007;Li et al, 2011). Glycoproteins in the AMK sample were the most prominent ingredients responsible for splenocyte stimulation and cytokine secretion (Lee et al, 2007). The polysaccharide fractions of AMK have been reported to improve humoral immunity in pigs (Li et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Atractylenolide I and acetylenic compound from AMK were found to be active compounds in different anti-inflammatory assays (Li et al, 2007). Glycoproteins from AMK markedly stimulated lymphocyte proliferation, antibody production, and cytokine secretion in mouse splenocytes (Lee et al, 2007). Those results indicated that the medicinal efficiency of AMK is related to its effective ingredient.…”

Section: Introductionmentioning

confidence: 88%

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The effects of supplementing diets with Atractylodes macrocephala Koidz rhizomes on growth performance and immune function in piglets

Xu¹,

Zhao²,

Shang³

et al. 2012

J. Anim. Feed Sci.

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The rhizome of Atractylodes macrocephala Koidz (baizhu in Chinese, AMK) is a well-known traditional Chinese medicine that has long been used as a digestive and tonic. The experiment was conducted to investigate the effect of baizhu powder on the growth performance and immune function of piglets. Duroc × Landrace×Yorkshire piglets (n=72, half males and half females, 42 days of age, liveweight 14.82±0.17 kg) were randomly allocated to three treatments: control, control+AMK either ground (GMD=180 μm), or micronized (GMD=5.59 μm), for 30 days. The results showed that supplementation with micronized baizhu significantly increased average daily gain (ADG) (P<0.05) and decreased (P<0.05) the feed/gain and diarrhoea ratios compared with the control group. Pigs given 80 mesh baizhu had a lower (P<0.05) diarrhoea ratio than those fed the control diet. Supplementation with 80 mesh baizhu and micronized baizhu significantly increased (P<0.05) both concanavalin-(ConA) and lipopolysaccharide (LPS)-induced splenocyte and peripheral lymphocyte proliferation, serum IgG, IL-1, and IL-2 concentrations (P<0.05) compared with the control group. In addition, supplementation with micronized baizhu significantly enhanced (P<0.05) PR-39 mRNA expression compared with the control group. The results indicate that baizhu could ameliorate metabolic status and regulate immune function to improve the growth performance of piglets, and that super-fine comminution may improve its medicinal efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

The effects of supplementing diets with Atractylodes macrocephala Koidz rhizomes on growth performance and immune function in piglets

Xu¹,

Zhao²,

Shang³

et al. 2012

J. Anim. Feed Sci.

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show abstract

“…Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979;Chen 1987;Huang et al, 1992;Lin et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…10 clinical efficacy, fixed processing method, and high quality. Ecological factors may play an important role in genuine herb formation, particularly when it comes to secondary metabolites' accumulation (Huang et al, 2007 …”

Section: Introductionmentioning

confidence: 99%

Chemical and ecological evaluation of a genuine chinese medicine Atractylodes macrocephala Koidz

Zhou¹,

Qu²,

Yu³

2011

Afr. J. Trad. Compl. Alt. Med.

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Validated Method for the Quantification of Atractylenolide III in Different Processed Products of Rhizoma Atractylodes Macrocephalae

Chen

Peng

Fang

et al. 2010

Phytochemical Analysis

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Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz.

Cited by 51 publications

References 8 publications

The effects of supplementing diets with <i>Atractylodes macrocephala</i> Koidz rhizomes on growth performance and immune function in piglets

The effects of supplementing diets with <i>Atractylodes macrocephala</i> Koidz rhizomes on growth performance and immune function in piglets

Chemical and ecological evaluation of a genuine chinese medicine <i>Atractylodes macrocephala</i> Koidz

Validated Method for the Quantification of Atractylenolide III in Different Processed Products of Rhizoma Atractylodes Macrocephalae

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