Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice

Wernicke, Dirk; Schulze-Westhoff, Claudia; Petrow, Peter; Br�uer, Rolf; Zacher, J.; Gay, Steffen

doi:10.1002/1529-0131(200201)46:1<64::aid-art10069>3.0.co;2-q

Cited by 23 publications

(11 citation statements)

References 47 publications

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“…This problem was underlined by the fact that contact with a certain type of matrix can induce differential MMP synthesis. 2 On the other hand, the present paper together with data derived from similar approaches examining the interaction between RA-SF and articular matrix or cartilage, support, at least in part, the hypothesis that these nonanimal models for RA may be sufficient or preferable for examining the pathophysiology at the sites of invasion and for the comparison with other arthritic synovial fibroblasts.…”

supporting

confidence: 72%

“…11 In total, about 20 members of the growing family of matrix MMPs are currently known (MMPs 1-3, 7-17, 19-21, 23, and 24), of which some belong to membrane-type (MT) MMPs-for example, MT1-MMP (MMP-14) and MT3-MMP (MMP- 16) and to the MMP subfamily of aggrecanases. 2 Numerous researchers have provided a large body of data showing that MMP-1 and MMP-3 are most important for joint destruction in RA. 10 The present study underlines this hypothesis by associating MMP-1 and MMP-3 expression directly with a functional parameter-that is, the number of cells that is actively passing through a matrix transwell system.…”

mentioning

confidence: 99%

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MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

Müller‐Ladner

2002

Annals of the Rheumatic Diseases

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supporting

confidence: 72%

mentioning

confidence: 99%

MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

Müller‐Ladner

2002

Annals of the Rheumatic Diseases

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“…Pannus tissue adheres to the surface of articular cartilage, and proliferating FLS within the pannus produce proteinases that degrade and destroy the cartilage and underlying cortical bone (31). A fully formed pannus is characterized by: proliferation of FLS; inflammatory infiltrates comprised predominantly of lymphocytes, plasma cells, and macrophages; and marked angiogenesis (32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

The regulatory role of nerve growth factor and its receptor system in fibroblast‐like synovial cells

Raychaudhuri¹,

Raychaudhuri

2009

Scandinavian Journal of Rheumatology

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Upregulation of NGF/TrkA in proinflammatory cytokine-activated FLS, the mitogenic effect of NGF on FLS, and the increased NGF level in SF of inflammatory arthritis suggest that there is cross-talk between NGF/NGF-R and FLS. These results also suggest that dysregulated production of NGF may lead to synovial cell proliferation and thus could influence the inflammatory and proliferative cascades of inflammatory arthritis.

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“…Regarding the process of cartilage degradation it was demonstrated that the adhesion of fibroblast-like cells to the cartilage is mediated via adhesion molecules, particularly VCAM-1 [25]. In this context, it was shown that in the synovial tissue collagenase 3 is predominantly expressed in fibroblast-like cells [26,27] and is strongly induced in fibroblast-like cells by contact with normal cartilage [28]. It remains to be elucidated whether (i) the expression of collagenase 3 in fibroblast-like cells is solely induced by cell -matrix interaction and proinflammatory cytokines, or (ii) reflects a certain step in the transformation and/or activation of fibroblast-like cells in RA.…”

Section: Discussionmentioning

confidence: 99%

The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis

Wernicke¹,

Seyfert²,

Stiehl

2006

Autoimmunity

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The histopathologic analysis of the synovial tissue is important to distinguish rheumatoid arthritis (RA) from other forms of synovitis and to provide information about prognosis and therapeutic strategies at early stages of the disease. In this context, the present study was performed to investigate the correlation between immunohistopathological and morphological features of synovitis and the expression of collagenase 3 (MMP-13) known to contribute significantly to cartilage degradation in RA. In the histopathologic scoring system used in this study, type I synovitis is characterized by B lymphocyte infiltration and an intact lining, and is only mild destructive to cartilage and bone. Type II shows marked diffuse infiltrations of macrophages and T lymphocytes, an ulcerated lining, fibrin exudation, and invasive growth into cartilage and bone tissue. Investigating 36 patients with RA, 21 patients (58%) were positive for the expression of collagenase 3 mRNA in the synovial tissue. Among these patients, 19 showed a histopathologic type II synovitis and only 2 patients had undifferentiated synovitis. In contrast, synovial tissue samples from patients without collagenase 3 mRNA expression were characterized in 6 cases by type I, in 5 cases by type II and in 4 cases by undifferentiated synovitis. The analysis of the clinical data revealed that RA patients with a histopathologic type II synovitis and synovial tissue collagenase 3 mRNA expression had elevated levels of systemic markers of inflammation and received stronger therapies. The data suggest, that collagenase 3 expression and the histopathologic type II synovitis are associated with a severe and destructive course of RA.

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Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice

Cited by 23 publications

References 47 publications

MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

The regulatory role of nerve growth factor and its receptor system in fibroblast‐like synovial cells

The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis

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