Stimulator design and subsequent stimulation parameter optimization for controlling micturition and reducing urethral resistance

Sawan, Mohamad; Hassouna, Magdy; Li, Jinsheng; Duval, F.; Elhilali, Mostafa

doi:10.1109/86.486056

Cited by 35 publications

(30 citation statements)

References 25 publications

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“…Recently, investigators in Montreal have focused on the 600 Hz conduction block produced by Solomonow, but using a biphasic waveform rather than a monophasic waveform (HAssOUNA et at., 1992;LI et at., 1995;SAWAN et al, 1996;SHAKER et at., 1998;ABDEL-GAWAD et at., 2001). Unlike the Solomonow waveform, the SaTan waveform has a zero net charge, as shown in Fig.…”

Section: Medical and Biological Engineering And Computing 2004 Vol 42mentioning

confidence: 94%

“…Sphincter pressure is utilised as the outcome measure. These investigators initially began their investigations utilising a 200-300 Hz waveform to produce a fast fatigue of the sphincter muscles to achieve a 'fatigue block' (HAsSOUNA et al, 1992;LI et al, 1995;SAWAN et al, 1996). They discovered, however, that if the frequency was increased to 600 Hz, they could achieve what appeared to be a true conduction block, rather that just a quickly fatiguing response.…”

Section: Medical and Biological Engineering And Computing 2004 Vol 42mentioning

confidence: 96%

“…isolated conditions in frog, rat, cat and dog models (CATTELL and GERARD, 1935;REBOUL and ROSENBLUETH, 1939;TANNER, 1962;Woo and CAMPBELL, 1964;SOLOMONOW et al, 1983;SOLOMONOW, 1984;BOWMAN and MCNEAL, 1986;ZHOU et al, 1987;BARATTA et al, 1989; RATTAY, 1990;HASSOUNA et al, 1992;ISHIGOOKA et al, 1994;LI et al, 1995;SAWAN et al, 1996;SHAKER et al, 1998;WILLIAMSON, 1999;ABDEL-GAWAD et al, 2001). However, the mechanism for this type of block is not known, and the reported results appear to be contradictory in many cases, in particular, it is not clear whether high-frequency nerve conduction block is due to a fatigue mechanism (HAsSOUNA et al, 1992) or to a true conduction block in the nerve membrane.…”

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confidence: 96%

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Nerve conduction block utilising high-frequency alternating current

Kilgore

Bhadra

2004

Med. Biol. Eng. Comput.

247

307

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High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3-5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 microCphase(-1). It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity.

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Section: Medical and Biological Engineering And Computing 2004 Vol 42mentioning

confidence: 94%

Section: Medical and Biological Engineering And Computing 2004 Vol 42mentioning

confidence: 96%

mentioning

confidence: 96%

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Nerve conduction block utilising high-frequency alternating current

Kilgore

Bhadra

2004

Med. Biol. Eng. Comput.

247

307

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“…An electrical impedance change of stimulation site is often due to fibrotic tissue presence around the electrode-nerve interface, which necessitates a change in the frequency to achieve the threshold of bladder enervation (SAWAN et al, 1996). The integration of the proposed electrode-nerve contact verification circuit with the employed stimulator can help optimise stimulation parameters.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, many electronic neuroprostheses intended for patients suffering from incontinence and retention disorders have been developed (SAWAN et al, 1996). if new technologies make it possible to generate a variety of stimuli waveforms with highly controlled parameters, stimulating electrodes and the surrounding tissues still remain a concern for long-term functional neurostimulation (FNS).…”

Section: Introductionmentioning

confidence: 99%

Implantable measurement technique dedicated to the monitoring of electrode-nerve contact in bladder stimulators

Donfack

Savaria

2000

Med. Biol. Eng. Comput.

Self Cite

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A fully integrated electrode-nerve contact monitoring circuit intended to increase safety and reliability in implantable bladder stimulators is described. The proposed integrated circuit converts a measurement of the impedance of two electrode-nerve contacts into frequency. The measurement is derived from a test current generated by the stimulation current source. The obtained results is the frequency of a square wave signal. This frequency is then converted into 8-bit data, which are serially transmitted to an external controller through an inductive link. The whole circuit can be set in idle model during stimulation, ensuring low energy consumption. It is fully testable, and an internal calibration technique makes it possible to reduce errors due to temperature and process variations. The total area of the proposed monitoring circuit is 0.1 mm2 when fabricated with a 0.35 micron technology, including a digitally controlled, current source. The design has been fabricated and successfully tested.

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Prosthetic Power Supplies

Djemouai

1999

Wiley Encyclopedia of Electrical and Electronics Engineering

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Stimulator design and subsequent stimulation parameter optimization for controlling micturition and reducing urethral resistance

Cited by 35 publications

References 25 publications

Nerve conduction block utilising high-frequency alternating current

Nerve conduction block utilising high-frequency alternating current

Implantable measurement technique dedicated to the monitoring of electrode-nerve contact in bladder stimulators

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