Stimuli‐Responsive Bio‐Based Quantum Dots in Biomedical Applications

Javanbakht, Siamak; Shaabani, Ahmad

doi:10.1002/9783527832095.ch28

Cited by 7 publications

(4 citation statements)

References 179 publications

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“…The toxicity of these nanoparticles is one significant barrier, but it is not yet fully understood. Before commercializing QDs for use in humans, we must conduct additional research on their potential toxicity, which will take time overall [105,[115][116][117][118].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Application of Quantum Dots in Bio-Sensing, Bio-Imaging, Drug Delivery, Anti-Bacterial Activity, Photo-Thermal, Photo-Dynamic Therapy, and Optoelectronic Devices

Rajamanickam¹

2023

Quantum Dots - Recent Advances, New Perspectives and Contemporary Applications

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Quantum dots (QDs) are of prevalent scientific and technological consideration because of their tunable size and thus frequency change (band-gap energy) in the NIR optical region. QDs have exceptional properties such as optical, physiochemical, electrical, and capacity to be bound to biomolecules. These selective size-dependent attributes of QDs assist them with having versatile applications in optoelectronic and biomedical fields. Their capacity to emit light at various frequencies because of an outer stimulus makes quantum dots perfect for use in imaging, diagnostics, tests for individual particles, and medication transportation frameworks. Ongoing advances in quantum dot design incorporate the potential for these nanocrystals to become therapeutic agents to restore numerous disease conditions themselves via bioconjugation with antibodies or medications. In this chapter, a few advances in the field of biomedical applications, such as bio-sensing, bio-imaging, drug loading capacity, targeted drug delivery, anti-stacking limit hostile to bacterial activity, photo-thermal treatment, photodynamic treatment, and optical properties for biomedical applications are presented, further to a short conversation on difficulties; for example, the biodistribution and harmful toxic effects of quantum dots is also discussed.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Application of Quantum Dots in Bio-Sensing, Bio-Imaging, Drug Delivery, Anti-Bacterial Activity, Photo-Thermal, Photo-Dynamic Therapy, and Optoelectronic Devices

Rajamanickam¹

2023

Quantum Dots - Recent Advances, New Perspectives and Contemporary Applications

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“…8,9 Thanks to these great properties, they are considered potent nanomaterials in a wide range of applications. [10][11][12][13][14] Citric acid is typically obtained from citrus fruits and over two million tons of it are produced each year. The abundant active sites, especially carboxylic functional groups, on the surface of citric acid-based GQDs make them particularly proficient in anchoring diverse metal ions or nanoparticles (NPs).…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Thanks to these great properties, they are considered potent nanomaterials in a wide range of applications. 10–14…”

Section: Introductionmentioning

confidence: 99%

Efficient anchoring of CuO nanoparticles on Ugi four-component-functionalized graphene quantum dots: colloidal soluble nanoplatform with great photoluminescent and antibacterial properties

et al. 2022

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“…Likewise, they have been broadly employed in white light-emitting diodes, optoelectronic devices, catalysis, drug delivery, chemo/biosensors, bioimaging, etc. [28,29]. Recently, a significant amount of research has been implemented on the synthesis of CQDs from bio-based materials, i.e., folic acid [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Gentamicin-loaded chitosan/folic acid-based carbon quantum dots nanocomposite hydrogel films as potential antimicrobial wound dressing

et al. 2022

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Background To provide effective healing in the wound, various carbohydrate polymers are commonly utilized that are highly potent platforms as wound dressing films. In this work, novel antibacterial flexible polymeric hydrogel films were designed via crosslinking polymeric chitosan (CS) with folic acid-based carbon quantum dots (CQDs). To end this, folic acid as a bio-precursor is used to synthesize CQDs through the hydrothermal technique. The synthesized CQDs as a crosslinking agent was performed at different concentrations to construct nanocomposite hydrogel films via the casting technique. Also, gentamicin (GM), L-Arginine and glycerol were supplemented in the formulation of nanocomposite since their antibiotic, bioactivity and plasticizing ability, respectively. Results The successful construction of films were verified with different methods (FT-IR, UV-Vis, PL, SEM, and AFM analyses). The GM release profile displayed a controlled release manner over 48 h with a low initial burst release in the simulated wound media (PBS, pH 7.4). Antibacterial and in vitro cytotoxicity results showed a significant activity toward different gram-positive and negative bacterial strains (about 2.5 ± 0.1 cm inhibition zones) and a desired cytocompatibility against Human skin fibroblast (HFF-1) cells (over 80% cell viability), respectively. Conclusion The obtained results recommend CQDs-crosslinked CS (CS/CQD) nanocomposite as a potent antimicrobial wound dressing. Graphical Abstract

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Stimuli‐Responsive Bio‐Based Quantum Dots in Biomedical Applications

Cited by 7 publications

References 179 publications

Application of Quantum Dots in Bio-Sensing, Bio-Imaging, Drug Delivery, Anti-Bacterial Activity, Photo-Thermal, Photo-Dynamic Therapy, and Optoelectronic Devices

Application of Quantum Dots in Bio-Sensing, Bio-Imaging, Drug Delivery, Anti-Bacterial Activity, Photo-Thermal, Photo-Dynamic Therapy, and Optoelectronic Devices

Efficient anchoring of CuO nanoparticles on Ugi four-component-functionalized graphene quantum dots: colloidal soluble nanoplatform with great photoluminescent and antibacterial properties

Gentamicin-loaded chitosan/folic acid-based carbon quantum dots nanocomposite hydrogel films as potential antimicrobial wound dressing

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