Stimuli-Responsive Microgels and Microgel-Based Systems: Advances in the Exploitation of Microgel Colloidal Properties and Their Interfacial Activity

Agrawal, Garima; Agrawal, Rahul

doi:10.3390/polym10040418

Cited by 84 publications

(59 citation statements)

References 199 publications

(259 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This method was successfully used to fabricate functional poly(ethylene glycol methacrylate phosphate) (PEGMP), 4‐vinylphenylboronic acid (PVPBA), and poly(hydroxyethylmethacrylate) (PHEMA) microgels. The readers are suggested to refer to several review articles and books for detailed information on precipitation polymerization technique …”

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

“…Stable microgels are obtained by employing crosslinking agents such as N , N′ ‐methylene‐bis‐acrylamide (BIS) in the monomer mixture . A variety of microgels including polyacrylic acid (PAA), polyacrylamide (PAAm), PNIPAM, and PHEMA, decorated with different functionalities, have been developed by using miniemulsion process . Readers are suggested to refer several research articles, review articles, and book chapters for detailed information on microgel synthesis by miniemulsion polymerization .…”

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

“…Readers are suggested to refer several research articles, review articles, and book chapters for detailed information on microgel synthesis by miniemulsion polymerization . This method not only provides the possibility of designing highly charged microgel particles but also the microgels based on hydrophilic monomers can be prepared via inverse miniemulsion method . However, the requirement of large amount of surfactant, and higher particle size and polydispersity index as compared to precipitation polymerization are the limitations of this method.…”

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

“…PNIPAM‐ and PVCL‐based microgel particles are the two most commonly investigated candidates among temperature‐responsive microgels . These microgels show a volume phase transition temperature (VPTT) above which the particles collapse drastically due to increased polymer–polymer interactions, thus releasing the encapsulated drug . Microgels having a VPTT above the normal body temperature are very attractive for drug delivery applications as the temperature in tumor cells is usually elevated, and additional hyperthermia can also be induced locally by a number of external heating techniques .…”

Section: Microgels For Drug Delivery Applicationmentioning

confidence: 99%

“…Additionally, their large surface area for multivalent bioconjugation, flexibility, and softness, superior colloidal stability, and stimuli‐responsive behavior enable them as a unique and versatile platform for various biomedical applications such as drug delivery, imaging, DNA or small interfering RNA (siRNA) delivery, and tissue regeneration . Several review articles have been reported in the literature and the readers are referred to them for detailed information on different fundamental aspects of microgels …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Functional Microgels: Recent Advances in Their Biomedical Applications

Agrawal

2018

Small

Self Cite

127

View full text Add to dashboard Cite

Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for various biomedical applications such as drug delivery, cell imaging, and tissue engineering. Herein, different synthetic methods to develop microgels with desirable functionality and properties along with degradable strategies to ensure their renal clearance are briefly presented. A special focus is given on the ability of microgels to respond to various stimuli such as temperature, pH, redox potential, magnetic field, light, etc., which helps not only to adjust their physical and chemical properties, and degradability on demand, but also the release of encapsulated bioactive molecules and thus making them suitable for drug delivery. Furthermore, recent developments in using the functional microgels for cell imaging and tissue regeneration are reviewed. The results reviewed here encourage the development of a new class of microgels which are able to intelligently perform in a complex biological environment. Finally, various challenges and possibilities are discussed in order to achieve their successful clinical use in future.

show abstract

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

Section: Methods For Designing Functional Microgelsmentioning

confidence: 99%

Section: Microgels For Drug Delivery Applicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional Microgels: Recent Advances in Their Biomedical Applications

Agrawal

2018

Small

Self Cite

127

View full text Add to dashboard Cite

show abstract

Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering

Xue

Yan

Deng

et al. 2021

Adv Funct Materials

327

180

View full text Add to dashboard Cite

Bone related diseases have caused serious threats to human health owing to their complexity and specificity. Fortunately, owing to the unique 3D network structure with high aqueous content and functional properties, emerging hydrogels are regarded as one of the most promising candidates for bone tissue engineering, such as repairing cartilage injury, skull defect, and arthritis. Herein, various design strategies and synthesis methods (e.g., 3D‐printing technology and nanoparticle composite strategy) are introduced to prepare implanted hydrogel scaffolds with tunable mechanical strength, favorable biocompatibility, and excellent bioactivity for applying in bone regeneration. Injectable hydrogels based on biocompatible materials (e.g., collagen, hyaluronic acid, chitosan, polyethylene glycol, etc.) possess many advantages in minimally invasive surgery, including adjustable physicochemical properties, filling irregular shapes of defect sites, and on‐demand release drugs or growth factors in response to different stimuli (e.g., pH, temperature, redox, enzyme, light, magnetic, etc.). In addition, drug delivery systems based on micro/nanogels are discussed, and its numerous promising designs used in the application of bone diseases (e.g., rheumatoid arthritis, osteoarthritis, cartilage defect) are also briefed in this review. Particularly, several key factors of hydrogel scaffolds (e.g., mechanical property, pore size, and release behavior of active factors) that can induce bone tissue regeneration are also summarized in this review. It is anticipated that advanced approaches and innovative ideas of bioactive hydrogels will be exploited in the clinical field and increase the life quality of patients with the bone injury.

show abstract

Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy

Gupta,

Sood,

Bhardwaj

et al. 2023

Advanced Therapeutics

Self Cite

View full text Add to dashboard Cite

Herein, we describe the fabrication of chitosan stabilized multifunctional hafnium oxide@gold core‐shell nanoparticles (HAT NPs) (≈12 nm). The developed nanoparticulate system offers multimodal action by providing stimuli responsive anticancer drug delivery along with imparting radiosensitization to cancer cells, thereby protecting surrounding normal tissues from damage. HAT NPs exhibit good capability of loading doxorubicin (DOX), an anticancer drug with ≈ 87% encapsulation efficiency. DOX loaded HAT NPs are able to release ≈ 91% DOX under GSH reducing conditions that is a representative of the cancer cell microenvironment. The cytotoxicity of the developed DOX loaded HAT NPs was tested against breast cancer cells (MDA‐MB‐231), showing higher cytotoxicity as compared to free DOX. Additionally, the ability of HAT NPs to generate ROS activity upon irradiation by gamma radiations (0.5 & 5 Gy) was also analysed in cancer cells to demonstrate the ability of synthesized system as a potent candidate to present radiosensitization. Further, in vivo biodistribution studies was executed to understand the tissue specific retention of HAT NPs for their future utility in targeted cancer treatment applications.This article is protected by copyright. All rights reserved

show abstract

Stimuli-Responsive Microgels and Microgel-Based Systems: Advances in the Exploitation of Microgel Colloidal Properties and Their Interfacial Activity

Cited by 84 publications

References 199 publications

Functional Microgels: Recent Advances in Their Biomedical Applications

Functional Microgels: Recent Advances in Their Biomedical Applications

Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering

Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy

Contact Info

Product

Resources

About