Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy

Qiao, Yiting; Wan, Jianqin; Zhou, Liqian; Wen, Ming‐Shien; Yang, Yuanyuan; Luo, Weixuan; Yu, Zhiqiang; Wang, Hangxiang

doi:10.1002/wnan.1527

Cited by 266 publications

(151 citation statements)

References 181 publications

(183 reference statements)

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“…These benefits include improved epithelium permeability, enhanced stability, extended halflife, increased solubility and bioavailability, improved tissue targeting as well as minimized side effects (Date et al, 2016;Kermanizadeh et al, 2018). The nanotechnology-based systems are increasingly applied now to prevent and cure aging-associated pathological conditions, including neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (Poovaiah et al, 2018;Ramanathan et al, 2018), cardiovascular diseases (Li et al, 2018;Taneja et al, 2019), obesity and type 2 diabetes (Bahadori et al, 2019;Tsou et al, 2019), and also tumors (Qiao et al, 2019).…”

Section: Therapeutic Advantages Of Nanodelivery Systemsmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

147

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Section: Therapeutic Advantages Of Nanodelivery Systemsmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

147

View full text Add to dashboard Cite

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“…When the rate of ROS production in the cells reached an undesired state, antioxidative machinery is activated to keep the cells in a proactive position. Therefore, having high capability for both oxidative and antioxidative machinery in cancer cells and sophisticated mechanisms over maintaining a balance between the two phenomenon has made cancer cells easily adopt to new environments for promotion of tumor growth (Qiao et al, 2018;Tsang et al, 2018). The role for melatonin here is to reduce the load of ROS on normal cells, instead, pushing this load toward cancer cells.…”

Section: Some Criteria Needed To Be Considered For Improving Therapmentioning

confidence: 99%

Adjuvant chemotherapy with melatonin for targeting human cancers: A review

Najafi

Salehi

Farhood

et al. 2018

Journal Cellular Physiology

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Melatonin is a multifunctional hormone that has long been known for its antitumoral effects. An advantage of the application of melatonin in cancer therapy is its ability to differentially influence tumors from normal cells. In this review, the roles of melatonin adjuvant therapy in human cancer are discussed. Combination of melatonin with chemotherapy could provide synergistic antitumoral outcomes and resolve drug resistance in affected patients. This combination reduces the dosage for chemotherapeutic agents with the subsequent attenuation of side effects related to these drugs on normal cells around tumor and on healthy organs. The combination therapy increases the rate of survival and improves the quality of life in affected patients. Cancer cell viability is reduced after application of the combinational melatonin therapy. Melatonin does all these functions by adjusting the signals involved in cancer progression, re-establishing the dark/light circadian rhythm, and disrupting the redox system for cancer cells. To achieve effective therapeutic outcomes, melatonin concentration along with the time of incubation for this indoleamine needs to be adjusted. Importantly, a special focus is required to be made on choosing an appropriate chemotherapy agent for using in combination with melatonin. Because of different sensitivities of cancer cells for melatonin combination therapy, cancer-specific targeted therapy is also needed to be considered. For this review, the PubMed database was searched for relevant articles based on the quality of journals, the novelty of articles published by the journals, and the number of citations per year focusing only on human cancers.

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“…Studies have taken advantage of the differences between the tumor microenvironment and the normal environment to figure out ways to release drugs from these nanoparticles. is has mainly been via dissociation of chemical bonds or structures that are sensitive to the tumor microenvironment [124,125].…”

Section: Drug Releasementioning

confidence: 99%

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

Xiong

et al. 2019

BioMed Research International

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Antitumor therapy using a combination of drugs has shown increased clinical efficacy. Active constituents derived from plants can offer several advantages, such as high efficiacy, low toxicity, extensive effects, and multiple targets. At present, the combination of plants’ active constituents and chemotherapeutic drugs has attracted increased attention. Nanodrug delivery systems (NDDSs) have been widely used in tumor-targeted therapy because of their efficacy of delivering antitumor drugs. The in vivo process of tumor-targeted NDDSs has several steps. They include blood circulation, tumor accumulation and penetration, target cell internalization and uptake, and drug release and drug response. In each step, NDDSs encounter multiple barriers that prevent their effective delivery to target sites. Studies have been performed to find alternative strategies to overcome these barriers. We reviewed the recent progress of codelivery of active constituents of plants and chemotherapeutics using NDDSs. Progress into transversing the physiological barriers for more effective in vivo antitumor delivery will be discussed in this review.

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Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy

Cited by 266 publications

References 181 publications

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Adjuvant chemotherapy with melatonin for targeting human cancers: A review

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

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