Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

Joseph, Shawn T.; Sabitha, M.; Nair, Sreeja C.

doi:10.15171/apb.2020.001

Cited by 25 publications

(10 citation statements)

References 90 publications

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“…PLGA (Poly-lactic-co-glycolic acid) is the frequently used polymer in this category with biodegradable and biocompatible features. These types of NPs can be produced by the addition of numerous monomeric molecules into different forms like 3 dimensional, linear, branched forms, etc [65]. The natural or synthetic type of PNPs are used for carriers of drugs or genes and can load siRNA (small interfering RNAs) and these are described as effective molecules to target the virus and have the ability to attack mutations in the virus.…”

Section: Polymeric Nanoparticles (Pnps)mentioning

confidence: 99%

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

et al. 2021

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The emerging Coronavirus Disease-19 (COVID-19) pandemic has had a global impact on all important aspects of our society. As it is known, SARS-Cov-2 can withstand up to 72 h in adverse environmental conditions, which can aid its rapid spread. Woefully, an efficacious and approbated vaccine for the SARS-CoV-2 virus remains unavailable, which makes the problem more frightening and presently more complicated bestowing forlorn medical care. Nevertheless, global clinical research is studying several over-the-counter (OTC) drugs approved for other indications to confront coronavirus. Over the past decade, therapeutic nanoparticles have been regarded as a felicitous tool for the efficient and persnickety delivery of therapeutic groups (i.e., drugs, vaccines, siRNAs, and peptides) to the site of infection. They can adequately convey the drug encapsulated nanoparticle to a designated locus without instigating unsought effects. Besides, they acquiesce the use of non-invasive imaging methods to monitor the surface of the infection and the response to treatment. The formulated nanoparticle is apposite for intranasal drug delivery which is a meritorious method to deliver therapeutic moiety for viral diseases affecting the lungs. Applying nanoparticles via intranasal route surmounted several demerits of mucosal administration like circumventing enzymatic degradation of the therapeutic moiety, upgrading and prolonging the action of the drug, etc., and can thus corroborate as an exceptional strategy to encounter respiratory viruses like coronavirus. In this article, we illuminate the promising role of nanoparticles as effective carriers of therapeutic or immunomodulatory agents to help combat COVID-19. The search criteria used were Pubmed, Medscape, Google scholar, etc and the keywords are coronavirus, nanoformulations, nanoparticles, drug delivery, intranasal delivery, etc. The articles range from 2012 to 2020.

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Section: Polymeric Nanoparticles (Pnps)mentioning

confidence: 99%

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

et al. 2021

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“…Surface groups Charge-charge interactions [68] The science of dendrimers can be considered as a combination of molecular and polymer chemistry. The step-by-step-controlled reactions of synthesis makes it a part of molecular chemistry, whereas the repetitive structure of dendrons (monomers) shows the role of it in polymer chemistry [69,70]. Dendrimers can be synthesized by the following methods:…”

Section: Fig 1: the Basic Structure Of A Dendrimer With Three Generatmentioning

confidence: 99%

An Updated Review on the Application of Dendrimers as Successful Nanocarriers for Brain Delivery of Therapeutic Moieties

et al. 2021

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It’s been nearly 100 y of effort to study the organization and role of the blood brain-barrier and still, we strive to find better techniques to overcome this barrier to deliver the drugs to the brain effectively with reduced systemic side effects. The advances in nanotechnology have given newer horizons in achieving this goal since the nano-scaled systems can modify an existing drug to have a high degree of sensitivity to the physiological conditions and specificity to reach the target organ. Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. The following search criteria were used to expand the review article with the keywords dendrimers, novel drug delivery, nanoparticles, site-specific drug delivery etc.

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“…55 There is still reliable evidence of biological and epigenetic effects on schizophrenia genetic disposition. 56 The use of blood cells to perform microarray studies has become increasingly popular due to the numerous advantages it provides, including the possibility to collect larger sample sizes with a minimally invasive procedure. 57 Genomic technology innovations have led to a better understanding of psychiatric disorders, providing information about numerous genes that affect brain development.…”

Section: Genetic Biomarkersmentioning

confidence: 99%

Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia

Rajalakshmi¹,

Menon²,

Nair³

2021

Adv Pharm Bull

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Schizophrenia is a neuropsychiatric disorder mainly affecting the central nervous system, presented with auditory and visual hallucinations, delusion and withdrawal from society. Abnormal dopamine levels mainly characterise the disease; various theories of neurotransmitters explain the pathophysiology of the disease. The current therapeutic approach deals with the systemic administration of drugs other than the enteral route, altering the neurotransmitter levels within the brain and providing symptomatic relief. Fluid biomarkers help in the early detection of the disease, which would improve the therapeutic efficacy. However, the major challenge faced in CNS drug delivery is the blood-brain barrier. Nanotherapeutic approaches may overcome these limitations, which will improve safety, efficacy, and targeted drug delivery. This review article addresses the main challenges faced in CNS drug delivery and the significance of current therapeutic strategies and nanotherapeutic approaches for a better understanding and enhanced drug delivery to the brain, which improve the quality of life of schizophrenia patients.

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Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

Cited by 25 publications

References 90 publications

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

An Updated Review on the Application of Dendrimers as Successful Nanocarriers for Brain Delivery of Therapeutic Moieties

Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia

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