Stimuli-responsive polymersomes for drug delivery applications

García, Mónica Cristina

doi:10.1016/b978-0-08-101995-5.00019-2

Cited by 15 publications

(35 citation statements)

References 133 publications

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“…They can effectively degrade the hyaluronan in tumor ECM and reduce IFP, enhancing nanocarrier penetration. microenvironment, such as stimuliresponsive (García, 2019b) or size-switching (Cabral et al, 2011) delivery platforms, are other strategies for enhancing cancer therapy. Size-switching nanocarriers are those with large particle size in blood circulation, which when become in contact with tumor tissue switch their size to small to effectively extravasate, leading to deep penetration (Cabral et al, 2011).…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

“…SAN represent a promising tool for targeted drug delivery, especially in personalized cancer treatments. They allow a site-directed delivery of anticancer therapeutics, increasing treatment efficacy and safety by modifying their physicochemical characteristics (i.e., size, shape, solubility, permeability) (García, 2019b;Yadav et al, 2020).…”

Section: Amphiphilic Block Copolymers and Self-assembled Nanocarriersmentioning

confidence: 99%

“…Even though passive and active targeting strategies contribute to intracellular accumulation of anticancer therapeutics, nanocarrier delivery performance can be improved by incorporating appropriate trigger responsiveness. Cutting-edge and emerging research focuses comprise the development of SAN since they can recognize some environmental clue, internal and/ or external stimuli ( Figure 1B), inducing physical/chemical changes and triggering cargo release in dose-, spatial-, and temporal-controlled manners (García, 2019b). Table 1 describes several examples of stimuli-responsive SAN and their application in cancer therapy.…”

Section: Stimuli-responsive Self-assembled Nanocarriersmentioning

confidence: 99%

“…Light irradiation, with variable intensity and wavelength, is an easy and low-cost exogenous stimulus. At a specific time and location, the disassembly of nanocarriers can be induced upon exposure to certain wavelengths, such as ultraviolet, visible, and near-infrared (NIR) (Che and van Hest, 2016;Johnson and Preman, 2018;García, 2019b). Light-responsive SAN frequently incorporate ABC with photo-sensitive moieties viz.…”

Section: Light-responsive Nanocarriersmentioning

confidence: 99%

“…Many delivery systems on nanoscale with significant achievements have been reported to date. Among them, amphiphilic block copolymers (ABC)-based self-assembled nanocarriers (SAN) for delivery of anticancer therapeutics have attracted researchers worldwide owing to their unique chemical and physical properties, improved biocompatibility, tunable compositions, extended blood circulation, and facile functionalization (Yin et al, 2016;García and Quiroz, 2018;García, 2019b). With the advancements in polymer chemistry, different ABC with preferred number and monomer type, each having different hydrophobic and hydrophilic properties have been synthetized (Yorulmaz Avsar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

et al. 2020

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Cancer is one of the most common life-threatening illness and it is the world’s second largest cause of death. Chemotherapeutic anticancer drugs have many disadvantages, which led to the need to develop novel strategies to overcome these shortcomings. Moreover, tumors are heterogenous in nature and there are various biological barriers that assist in treatment reisistance. In this sense, nanotechnology has provided new strategies for delivery of anticancer therapeutics. Recently, delivery platforms for overcoming biological barriers raised by tumor cells and tumor-bearing hosts have been reported. Among them, amphiphilic block copolymers (ABC)-based self-assembled nanocarriers have attracted researchers worldwide owing to their unique properties. In this work, we addressed different biological barriers for effective cancer treatment along with several strategies to overcome them by using ABC‐based self-assembled nanostructures, with special emphasis in those that have the ability to act as responsive nanocarriers to internal or external environmental clues to trigger release of the payload. These nanocarriers have shown promising properties to revolutionize cancer treatment and diagnosis, but there are still challenges for their successful translation to clinical applications.

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Section: Tumor Microenvironmentmentioning

confidence: 99%

Section: Amphiphilic Block Copolymers and Self-assembled Nanocarriersmentioning

confidence: 99%

Section: Stimuli-responsive Self-assembled Nanocarriersmentioning

confidence: 99%

Section: Light-responsive Nanocarriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

et al. 2020

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Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC-associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design-based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever-increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design-based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi-stimuli-responsive and multi-drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area.

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Polymersomes for Targeted Drug and Gene Delivery Systems

Silva

Ricardo

et al. 2022

Nanotechnology in the Life Sciences

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Stimuli-responsive polymersomes for drug delivery applications

Cited by 15 publications

References 133 publications

Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Polymersomes for Targeted Drug and Gene Delivery Systems

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